Results 51 to 60 of about 212,832 (300)

Reduced nephrin tyrosine phosphorylation impairs podocyte force transmission and accelerates detachment in disease

iScience
Summary: Podocytes are specialized kidney cells that form the slit diaphragm (SD), an intercellular filtration barrier against plasma protein loss. The SD is subject to significant mechanical strain which can be amplified in disease, leading to podocyte ...
Casey R. Williamson, Claire E. Martin, J. Dinesh Kumar, Peihua Lu, Laura A. New, Alice Y. Wang, Nils M. Kronenberg, Malte C. Gather, Paul A. Reynolds, Nina Jones   +9 more
doaj   +1 more source

Diversity and functional specialization of oyster immune cells uncovered by integrative single-cell level investigations [PDF]

eLife
Mollusks are a major component of animal biodiversity and play a critical role in ecosystems and global food security. The Pacific oyster, Crassostrea (Magallana) gigas , is the most farmed bivalve mollusk in the world and is becoming a model species for invertebrate biology.
de la Forest Divonne, Sébastien, Pouzadoux, Juliette, Romatif, Océane, Montagnani, Caroline, Mitta, Guillaume, Destoumieux-Garzon, Delphine, Gourbal, Benjamin, Charrière, Guillaume, Vignal, Emmanuel   +8 more
openaire   +4 more sources

Prognostic Impact of Treatment Modalities, Including Targeted Compartmental Radio‐Immunotherapy, in a Cohort of Neuroblastoma Patients With CNS Metastases at Relapse

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neuroblastoma (NB) with central nervous system (CNS) metastases is rare at diagnosis, but occurs more often during relapse/progression. Patients with CNS metastases face a dismal prognosis, with no standardized curative treatment available.
Vicente Santa‐Maria Lopez, Anna Felip‐Badia, Marina Caballero‐Bellon, Nazaret Sanchez‐Sierra, Alicia Castañeda, Moira Garraus, Maite Gorostegui, Margarida Simão‐Rafael, Juan Pablo Muñoz, Marta Perez‐Somarriba, Salvador Mañe, Mariana Cecilia Planells, Sara Perez‐Jaume, Jaume Mora   +13 more
wiley   +1 more source

Functional specialization of intestinal dendritic cell subsets during Th2 helminth infection in mice [PDF]

European Journal of Immunology, 2017
AbstractDendritic cells (DCs) are essential in dictating the nature and effectiveness of immune responses. In the intestine DCs can be separated into discrete subsets, defined by expression of CD11b and CD103, each with different developmental requirements and distinct functional potential. Recent evidence has shown that different intestinal DC subsets
Stephen A. Redpath, Graham A. Heieis, Lisa A. Reynolds, Nicolette M. Fonseca, Sandra S.‐Y. Kim, Georgia Perona‐Wright   +5 more
openaire   +3 more sources

Developmental Disorders in Children Recently Diagnosed With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Neurocognitive deficits in adult survivors of childhood cancer are well established, but less is known about developmental disorders (DD) arising shortly after cancer diagnosis. Using 2016–2019 linked Ohio cancer registry and Medicaid data, we compared DD among 324 children with cancer and 606,913 cancer‐free controls.
Jamie Shoag, Long Vu, Ritika Miryala, Jeffrey M. Albert, Molly McVoy, Siran M. Koroukian   +5 more
wiley   +1 more source

The unanticipated role of the glial-associated glucose-6-phosphatase system in brain homeostasis

iScience
The glucose-6-phosphatase (G6Pase) system is a multiprotein complex within the endoplasmic reticulum that enables glucose export during high energy demand.
María José Barahona, Katterine Salazar, Francisco Nualart   +2 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Actin maintains synaptic transmission by restraining vesicle release probability

iScience
Summary: Despite decades of pharmacological studies, how the ubiquitous cytoskeletal actin regulates synaptic transmission remains poorly understood. We addressed this issue with a tissue-specific knockout of actin β-isoform or γ-isoform, combined with ...
Xin-Sheng Wu, Zhen Zhang, Yinghui Jin, Afreen Mushtaheed, Ling-Gang Wu   +4 more
doaj   +1 more source

Functional specialization of human circulating CD16 and CD1c myeloid dendritic-cell subsets

Blood, 2007
AbstractHuman blood contains 2 populations of dendritic cells (DCs): plasmacytoid and myeloid (mDC). mDCs are subdivided into 3 subsets using the surface markers CD16, CD1c, and BDCA-3. Their role as pathogen sentinels and adjuvant targets was tested by phenotypic and functional analysis.
Piccioli D., Tavarini S., Borgogni E., Steri V., Nuti S., Sammicheli C., Bardelli M., Montagna D., Locatelli F., Wack A.   +9 more
openaire   +5 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source