Results 71 to 80 of about 501,668 (378)

Cleaved intracellular SNARE peptides are implicated in a novel cytotoxicity mechanism of botulinum serotype C [PDF]

, 2013
Recent advances in intracellular protein delivery have enabled more in-depth analyses of cellular functions. A specialized family of SNARE proteases, known as Botulinum Neurotoxins, blocks neurotransmitter exocytosis, which leads to systemic toxicity ...
Arsenault, Jason, Cuijpers, Sabine A. G., Davletov, Bazbek, Ferrari, Enrico, Niranjan, Dhevahi, O'Brien, John A.   +5 more
core   +1 more source

Functions of the Salmonella pathogenicity island 2 (SPI-2) type III secretion system effectors.

Microbiology, 2012
Salmonella enterica serovars cause severe disease in humans, such as gastroenteritis and typhoid fever. The bacteria are able to invade and replicate within host cells, including epithelial cells and macrophages. Pathogenesis of Salmonella is facilitated
Rita Figueira, D. Holden
semanticscholar   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Cloned mouse cells with natural killer function and cloned suppressor T cells express ultrastructural and biochemical features not shared by cloned inducer T cells. [PDF]

, 1983
We have examined the morphology, cytochemistry, and biochemistry of mouse leukocyte subsets by analyzing cloned leukocyte populations specialized to perform different immunologic functions.
Cantor, H, der Simonian, H, Dvorak, AM, Dvorak, HF, Galli, SJ, Goldin, J, Marcum, JA, Monahan, RA, Nabel, G, Pyne, K, Rosenberg, RD   +10 more
core  

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Optimal measurement of visual motion across spatial and temporal scales [PDF]

, 2014
Sensory systems use limited resources to mediate the perception of a great variety of objects and events. Here a normative framework is presented for exploring how the problem of efficient allocation of resources can be solved in visual perception ...
A Gorban, A Gorban, A Jones, AB Watson, AJ Doorn van, AJ Doorn van, B Krekelberg, B Sakitt, CW Gardiner, CWG Clifford, D Gabor, D Marr, DH Kelly, DH Kelly, DJ Field, DM MacKay, DO Hebb, EL Bienenstock, EP Simoncelli, ET Jaynes, G Bi, HL Resnikoff, JG Daugman, K Nakayama, LA Lesmes, M Kubovy, M Vergassola, M Wertheimer, MJ Wainwright, MS Landy, O Paulsen, P Burt, P Jurica, RD Luce, S Gepshtein, S Gepshtein, S Gepshtein, S Gepshtein, S Gepshtein, S Marcelja, S Saremi, SB Laughlin, SB Laughlin, TM Cover, VD Glezer, Y Weiss, Y Yeshurun, Y Yeshurun   +47 more
core   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Reduced nephrin tyrosine phosphorylation impairs podocyte force transmission and accelerates detachment in disease

iScience
Summary: Podocytes are specialized kidney cells that form the slit diaphragm (SD), an intercellular filtration barrier against plasma protein loss. The SD is subject to significant mechanical strain which can be amplified in disease, leading to podocyte ...
Casey R. Williamson, Claire E. Martin, J. Dinesh Kumar, Peihua Lu, Laura A. New, Alice Y. Wang, Nils M. Kronenberg, Malte C. Gather, Paul A. Reynolds, Nina Jones   +9 more
doaj   +1 more source

Differentiated cell behavior: a multiscale approach using measure theory

, 2014
This paper deals with the derivation of a collective model of cell populations out of an individual-based description of the underlying physical particle system.
Colombi, Annachiara, Scianna, Marco, Tosin, Andrea   +2 more
core   +1 more source

De novo formation of an aggregation pheromone precursor by an isoprenyl diphosphate synthase-related terpene synthase in the harlequin bug. [PDF]

, 2018
Insects use a diverse array of specialized terpene metabolites as pheromones in intraspecific interactions. In contrast to plants and microbes, which employ enzymes called terpene synthases (TPSs) to synthesize terpene metabolites, limited information ...
Ghosh, Saikat Kumar B, Gundersen-Rindal, Dawn E, Khrimian, Ashot, Kuhar, Thomas P, Köllner, Tobias G, Lancaster, Jason, Lehner, Bryan, Luck, Katrin, Marek, Paul E, Muchlinski, Andrew, Sparks, Michael E, Tholl, Dorothea, Tittiger, Claus, Tokuhisa, James G, Wallingford, Anna, Weber, Donald C, Young, Sharon, Zerbe, Philipp   +17 more
core   +3 more sources