Results 81 to 90 of about 503,791 (335)

Lectins and Tetrahymena – A review [PDF]

, 2016
The unicellular ciliate Tetrahymena is a complete organism, one of the most highly developed protozoans, which has specialized organelles performing each of the functions characteristic to the cells of higher ranked animals.
Csaba, György
core   +1 more source

Functional specialization of human circulating CD16 and CD1c myeloid dendritic-cell subsets

Blood, 2007
AbstractHuman blood contains 2 populations of dendritic cells (DCs): plasmacytoid and myeloid (mDC). mDCs are subdivided into 3 subsets using the surface markers CD16, CD1c, and BDCA-3. Their role as pathogen sentinels and adjuvant targets was tested by phenotypic and functional analysis.
Piccioli D., Tavarini S., Borgogni E., Steri V., Nuti S., Sammicheli C., Bardelli M., Montagna D., Locatelli F., Wack A.   +9 more
openaire   +5 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Astrocytic FABP5 mediates retrograde endocannabinoid transport at central synapses

iScience
Summary: Endocannabinoids (eCBs) regulate synaptic function via cannabinoid receptors. While eCB signaling is well understood, the mechanisms underlying eCB synaptic transport are poorly characterized.
Saida Oubraim, Mohammad Fauzan, Keith Studholme, Chris Gordon, Sherrye T. Glaser, Roh-Yu Shen, Iwao Ojima, Martin Kaczocha, Samir Haj-Dahmane   +8 more
doaj   +1 more source

De novo formation of an aggregation pheromone precursor by an isoprenyl diphosphate synthase-related terpene synthase in the harlequin bug. [PDF]

, 2018
Insects use a diverse array of specialized terpene metabolites as pheromones in intraspecific interactions. In contrast to plants and microbes, which employ enzymes called terpene synthases (TPSs) to synthesize terpene metabolites, limited information ...
Ghosh, Saikat Kumar B, Gundersen-Rindal, Dawn E, Khrimian, Ashot, Kuhar, Thomas P, Köllner, Tobias G, Lancaster, Jason, Lehner, Bryan, Luck, Katrin, Marek, Paul E, Muchlinski, Andrew, Sparks, Michael E, Tholl, Dorothea, Tittiger, Claus, Tokuhisa, James G, Wallingford, Anna, Weber, Donald C, Young, Sharon, Zerbe, Philipp   +17 more
core   +3 more sources

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

The Proton-Sensing GPR4 Receptor Regulates Paracellular Gap Formation and Permeability of Vascular Endothelial Cells

iScience, 2020
Summary: GPR4 is a pH-sensing G protein-coupled receptor highly expressed in vascular endothelial cells and can be activated by protons in the inflamed tissue microenvironment.
Elizabeth A. Krewson, Edward J. Sanderlin, Mona A. Marie, Shayan Nik Akhtar, Juraj Velcicky, Pius Loetscher, Li V. Yang   +6 more
doaj   +1 more source

Parallel and convergent processing in grid cell, head-direction cell, boundary cell, and place cell networks. [PDF]

, 2013
The brain is able to construct internal representations that correspond to external spatial coordinates. Such brain maps of the external spatial topography may support a number of cognitive functions, including navigation and memory.
Brandon, Mark P, Koenig, Julie, Leutgeb, Stefan   +2 more
core   +2 more sources

Human dendritic cell subsets: An updated view of their ontogeny and functional specialization

European Journal of Immunology, 2022
Abstract Human DCs have been divided into several subsets based on their phenotype and ontogeny. Recent high throughput single‐cell methods have revealed additional heterogeneity within human DC subsets, and new subpopulations have been proposed.
openaire   +3 more sources