Results 101 to 110 of about 1,566,030 (299)
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
30-Year-Long Changes in Terrestrial Vertebrate Fauna of Niebieskie ŹródłA (Blue Springs) Nature Reserve in Tomaszów Mazowiecki, Central Poland [PDF]
, 2010 The article focuses on changes in terrestrial vertebrate fauna of Niebieskie Źródła (Blue Springs) Nature Reserve that occurred between two censuses carried out in the area.
Hejduk, Janusz +3 more
core +2 more sources
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Alternative sampling and estimation methods for multispecies trawl surveys [PDF]
, 2004 Thesis (Ph.D.) University of Alaska Fairbanks, 2004Multispecies demersal trawl surveys are used in the United States and internationally to estimate the relative abundance of commercial and non-commercial fish species.
Dressel, Sherri Christine
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Using poststratification to improve abundance estimates from multispecies surveys: a study of juvenile flatfishes [PDF]
, 2005 Population assessments seldom incorporate habitat information or use previously observed distributions of fish density. Because habitat affects the spatial distribution of fish density and overall abundance, the use of habitat information and previous ...
Dressel, Sherri C.
core
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
The CC-Bio Project: Studying the Effects of Climate Change on Quebec Biodiversity
Diversity, 2010 Anticipating the effects of climate change on biodiversity is now critical for managing wild species and ecosystems. Climate change is a global driver and thus affects biodiversity globally.
Luc Vescovi +18 more
doaj +1 more source