Results 151 to 160 of about 6,846,802 (336)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Streptococcus Species Abundance in the Gut Is Linked to Subclinical Coronary Atherosclerosis in 8973 Participants From the SCAPIS Cohort. [PDF]

open access: yesCirculation, 2023
Sayols-Baixeras S   +29 more
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

open access: yesFEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart   +7 more
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

open access: yesFEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik   +6 more
wiley   +1 more source

Seasonal Abundance, Movement and Diversity of Fishes in an Ozark Stream [PDF]

open access: yes, 1981
Seasonal fluctuations in fish abundance in Mud Creek occurred throughout the year at all sampling stations. At the two upper stations abundance was high and unstable during winter and early spring and decreased after heavy rainfall in mid-April ...
Dewey, Michael R.
core   +2 more sources

Global sustainability scenarios lead to regionally different outcomes for terrestrial biodiversity

open access: yesEnvironmental Research Letters
Mitigating climate change (CC) and reversing biodiversity decline are urgent and interconnected global priorities. Strategies to address both crises must consider the relationships, synergies and trade-offs between key response measures, including ...
Geanderson Ambrósio   +4 more
doaj   +1 more source

Predicting climate change impacts on poikilotherms using physiologically guided species abundance models. [PDF]

open access: yesProc Natl Acad Sci U S A, 2023
Wagner T   +6 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

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