Design and analysis strategies for robust microbiome ageing research
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Habitat mapping and species distribution modelling of the endangered Bulloak Jewel Butterfly [PDF]
Assessing and mapping of wildlife habitat plays a vital role in the development of management plans and conservation strategies. Habitat assessment commonly involves the estimation of population size, identification of critical habitat and prediction of ...
Abdullah, Wan Nor Zanariah Zainol
core
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
occupancyTuts: Occupancy modelling tutorials with RPresence
The occupancy modelling framework offers tremendous flexibility in estimating species abundance and distribution patterns while accounting for imperfect detection, and has seen rapid growth and adoption since its introduction at the beginning of the ...
Therese Donovan +2 more
doaj +1 more source
Species distribution modelling using MaxEnt: overview and prospects
Niche modeling of species has become increasingly important in the context of accelerating climate change and anthropogenic impacts on the biosphere. One such tool for predicting the potential distribution of species is the maximum entropy method (MaxEnt)
Yuliia Novoseltseva
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Evaluation of climate conditions and ecological traits that limit the distribution expansion of alien Lolium rigidum in Japan [PDF]
Invasive alien plants cause severe global problems; therefore, determining the factors that lead to the success or failure of invasion is a critical question in the field of invasion ecology.
Kentaro Uehira, Yoshiko Shimono
doaj +3 more sources
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Species Distribution and Forest Type Mapping in Mexico [PDF]
The study analyzed the potential of multi-temporal satellite remote sensing data (Terra-MODIS) for phenological studies in Mexico. Within two conceptually and methodologically independent approaches, we analyzed vegetation index data to continuously ...
Cord, Anna +7 more
core +1 more source

