Results 81 to 90 of about 95,111 (302)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Genetic monitoring detects an overlooked cryptic species and reveals the diversity and distribution of three invasive Rattus congeners in South Africa [PDF]

, 2011
Background: South Africa's long and extensive trade activity has ensured ample opportunities for exotic species introduction. Whereas the rich biodiversity of endemic southern African fauna has been the focus of many studies, invasive vertebrates are ...
Jennifer M Lamb, von Maltitz Emil, van Hooft, W.F., Deenadayalan Nair, Chimimba, C.T., Taylor Peter J, van Hooft, Pim, Lamb3, Jennifer M., Mostert, Elmarie, Downs Sarah, Christian T Chimimba, Kirsten, F., Contrafatto Giancarlo, Brettschneider, Helene, Emil von Maltitz, Giancarlo Contrafatto, Downs, Sarah, Steven R Belmain, Brettschneider, H., Chimimba, Christian Timothy, Sarah Downs, Bastos Armanda D, Nair, Deenadayalan, Helene Brettschneider, Belmain, Steven R., Contrafatto, Giancarlo, Nair Deenadayalan, Contrafatto, G., Lamb Jennifer M, Lamb, J.M., Taylor, Peter J., Lamb, Jennifer M., Maltitz, E., Nair, D., Kirsten, Frikkie, Elmarie Mostert, Peter J Taylor, van Hooft Pim, Chimimba, Christian T., Bastos, Armanda D., Kirsten Frikkie, Downs, S., Taylor, P.J., Taylor, P.J. (Peter John), von Maltitz, Emil, Belmain Steven R, Armanda D Bastos, Mostert, E., Bastos, Armanda D.S., Pim van Hooft, Hooft, W.F., van, Chimimba Christian T, Bastos, A.D.S., Frikkie Kirsten, Mostert Elmarie, Brettschneider Helene, Belmain, S.R., Maltitz, Emil von   +57 more
core   +1 more source

Silvicolous on a small scale: possibilities and limitations of habitat suitability models for small, elusive mammals in conservation management and landscape planning.

PLoS ONE, 2015
Species distribution and endangerment can be assessed by habitat-suitability modelling. This study addresses methodical aspects of habitat suitability modelling and includes an application example in actual species conservation and landscape planning ...
Nina I Becker, Jorge A Encarnação
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Tools and approaches for mapping Marine Animal Forests: A practical overview for researchers and conservationists [version 2; peer review: 1 approved, 2 approved with reservations]

Open Research Europe
Mapping marine animal forests (MAFs) is essential for understanding complex benthic ecosystems and supporting their conservation and management. This review provides a comprehensive overview of the key aspects of MAFs that can be mapped, focusing on both
Laurence H. De Clippele, Miquel Canals, Ricardo Aguilar, Laura Martín-García, Giovanni Chimienti, Bogdan Prodanov, Iliyan Kotsev, Beatriz Vinha, Dimitris Poursanidis   +8 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Modelling the spatial distribution of three marine fish species in the southern Benguela

, 2013
Understanding the spatial distribution of species in relationship to climatic and environmental variables is key to conservation and management of important species, as their distribution might change under climate change and variability.
Wilkes, Chris
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Range expansion of Ambrosia artemisiifolia in Europe is promoted by climate change [PDF]

, 2013
Ambrosia artemisiifolia L., native to North America, is a problematic invasive species, because of its highly allergenic pollen. The species is expected to expand its range due to climate change.
Cunze, Sarah, Tackenberg, Oliver, Leiblein, Marion Carmen   +2 more
core   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source