Results 81 to 90 of about 9,404,650 (282)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Predicting future European breeding distributions of British seabird species under climate change and unlimited/no dispersal scenarios [PDF]

, 2015
We thank the European Bird Census Council for their data on European seabird distributions. DJFR was supported by NERC UKPopNet.Understanding which traits make species vulnerable to climatic change and predicting future distributions permits conservation
Huntley, Brian, Wanless, S., Sarah Wanless, Huntley, B., Yvonne Collingham, Deborah Russell, Hamer, Keith C., Collingham, Y., Russell, Deborah J.F., Brian Huntley, Deborah J.F. Russell, Keith C. Hamer, Hamer, K., Russell, Deborah Jill Fraser, Yvonne C. Collingham, Wanless, Sarah, Collingham, Yvonne C., Russell, D., Keith Hamer   +18 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Tools and approaches for mapping Marine Animal Forests: A practical overview for researchers and conservationists [version 2; peer review: 1 approved, 2 approved with reservations]

Open Research Europe
Mapping marine animal forests (MAFs) is essential for understanding complex benthic ecosystems and supporting their conservation and management. This review provides a comprehensive overview of the key aspects of MAFs that can be mapped, focusing on both
Laurence H. De Clippele, Miquel Canals, Ricardo Aguilar, Laura Martín-García, Giovanni Chimienti, Bogdan Prodanov, Iliyan Kotsev, Beatriz Vinha, Dimitris Poursanidis   +8 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Silvicolous on a small scale: possibilities and limitations of habitat suitability models for small, elusive mammals in conservation management and landscape planning.

PLoS ONE, 2015
Species distribution and endangerment can be assessed by habitat-suitability modelling. This study addresses methodical aspects of habitat suitability modelling and includes an application example in actual species conservation and landscape planning ...
Nina I Becker, Jorge A Encarnação
doaj   +1 more source

A Review of Potential Impacts of Climate Change on Coffee Cultivation and Mycotoxigenic Fungi

Microorganisms, 2020
Coffee is one of the most traded commodities in the world. It plays a significant role in the global economy, employing over 125 million people. However, it is possible that this vital crop is threatened by changing climate conditions and fungal ...
Mira Adhikari, Elizabeth L. Isaac, R. Russell M. Paterson, Mark A. Maslin   +3 more
doaj   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Spatial prioritization of selected mining pitlakes from Eastern Coalfields region, India: A species distribution modelling approach

Conservation Science and Practice, 2020
Pitlake conservation is still a naive idea in a developing country. Species distribution modelling approaches can prove to be a useful tool in protecting biodiversity.
Snehangshu Das, Aparajita Mukherjee, Santanu Gupta   +2 more
doaj   +1 more source

Inferring the similarity of species distributions using Species’ Distribution Models

Ecography, 2013
A common problem in ecology is our need to reliably compare information on the distributions of distinct species. Since it is not always possible to directly compare the distributions of two species, numerous papers now seek to compare the predictions of Species’ Distribution Models (SDMs, estimates of the probability that two species are present ...
openaire   +2 more sources