Results 91 to 100 of about 9,824,356 (289)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

A multi-scale modelling framework to guide management of plant invasions in a transboundary context

Forest Ecosystems, 2016
Background Attention has recently been drawn to the issue of transboundary invasions, where species introduced and naturalized in one country cross international borders and become problematic in neighbouring countries. Robust modelling frameworks, able
João Martins, David M. Richardson, Renato Henriques, Elizabete Marchante, Hélia Marchante, Paulo Alves, Mirijam Gaertner, João P. Honrado, Joana R. Vicente   +8 more
doaj   +1 more source

Adaptive management, international co-operation and planning for marine conservation hotspots in a changing climate [PDF]

, 2015
The aim of this study is to predict changes in the distribution and extent of habitat forming species defined as “Priority Marine Habitats” (PMHs) in the North-East (NE) Atlantic under future scenarios of climate-induced environmental change.
Sanderson, William G., Bell, Michael C., Gormley, Kate Sarah Geddes, Gormley, Kate S. G., Hull, Angela, Hull, Angela D., Porter, Joanne S., Bell, Michael, Porter, Joanne; id_orcid, Sanderson, William; id_orcid   +9 more
core   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Tools and approaches for mapping Marine Animal Forests: A practical overview for researchers and conservationists

Open Research Europe
Mapping marine animal forests (MAFs) is essential for understanding complex benthic ecosystems and supporting their conservation and management. This review provides a comprehensive overview of the key aspects of MAFs that can be mapped,
Laurence H. De Clippele, Ricardo Aguilar, Miquel Canals, Giovanni Chimienti, Laura Martín-García, Iliyan Kotsev, Bogdan Prodanov, Dimitris Poursanidis, Beatriz Vinha   +8 more
doaj   +1 more source

A Review of Potential Impacts of Climate Change on Coffee Cultivation and Mycotoxigenic Fungi

Microorganisms, 2020
Coffee is one of the most traded commodities in the world. It plays a significant role in the global economy, employing over 125 million people. However, it is possible that this vital crop is threatened by changing climate conditions and fungal ...
Mira Adhikari, Elizabeth L. Isaac, R. Russell M. Paterson, Mark A. Maslin   +3 more
doaj   +1 more source

Inferring the similarity of species distributions using Species’ Distribution Models

Ecography, 2013
A common problem in ecology is our need to reliably compare information on the distributions of distinct species. Since it is not always possible to directly compare the distributions of two species, numerous papers now seek to compare the predictions of Species’ Distribution Models (SDMs, estimates of the probability that two species are present ...
openaire   +2 more sources