Results 101 to 110 of about 9,404,650 (282)

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

open access: yesFEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss   +7 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

open access: yesFEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks   +4 more
wiley   +1 more source

Variation in Spatial Predictions Among Species Distribution Modeling Methods [PDF]

open access: yes
Prediction maps produced by species distribution models (SDMs) influence decision-making in resource management or designation of land in conservation planning. Many studies have compared the prediction accuracy of different SDM modeling methods, but few
Alexandra D. Syphard, Janet Franklin
core  

Developing a quantitative indicator to monitor cetacean distributional change

open access: yesEcological Indicators
Monitoring the distribution of cetaceans is a priority in marine conservation. However, current ecosystem-wide assessments lack indicators on distribution: cetacean distribution maps fall short of quantitative reporting purposes.
Vincent Benoit   +2 more
doaj   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

open access: yesFEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito   +7 more
wiley   +1 more source

Uncertainty in ensembles of global biodiversity scenarios

open access: yesNature Communications, 2019
Attaining global biodiversity projections requires the use of various species distribution and climate modelling and scenario approaches. Here the authors report that model choice can significantly impact results, with particularly uncertainty arising ...
Wilfried Thuiller   +4 more
doaj   +1 more source

Modelling species distribution at the boundaries of the Earth's climate

open access: yesGlobal Ecology and Biogeography
11institutetext: Knowledge-based Systems and Document Processing Research Group Faculty of Computer Science Otto-von-Guericke-University Magdeburg 11email: katrin.krieger@ovgu.de Correlative species distribution models (SDMs) are widely used to project the responses of biodiversity to global changes.
Serafini C.   +3 more
openaire   +2 more sources

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

open access: yesFEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez   +6 more
wiley   +1 more source

Postglacial migration supplements climate in determining plant species ranges in Europe [PDF]

open access: yes, 2011
The influence of dispersal limitation on species ranges remains controversial. Considering the dramatic impacts of the last glaciation in Europe, species might not have tracked climate changes through time and, as a consequence, their present-day ranges ...
Oliver Tackenberg   +11 more
core   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

open access: yesFEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli   +3 more
wiley   +1 more source

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