Results 121 to 130 of about 9,404,650 (282)

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

open access: yesFEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima   +8 more
wiley   +1 more source

Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone   +8 more
wiley   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu   +21 more
wiley   +1 more source

Moving Beyond Static Species Distribution Models in Support of Conservation Biogeography [PDF]

open access: yes
Aim: To demonstrate that multi-modeling methods have effectively been used to combine static species distribution models (SDM), predicting the geographical pattern of suitable habitat, with dynamics landscape and population models in order to forecast ...
Janet Franklin
core  

Longitudinal Assessment of Biomarkers in ALS: Discriminative Biomarkers for Disease Progression and Survival

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers   +7 more
wiley   +1 more source

Factors affecting the distribution of three non-indigenous riparian weeds in north-east England [PDF]

open access: yes, 1999
The work presented uses a multi-disciphnary approach to examine the factors important in determining the distribution of the non-indigenous species, Impatiens glandulifera, Heracleum mantegazzianum and Fallopia japonica at a river catchment level ...
Willis, Stephen Geoffrey
core  

BAYESIAN MODELS FOR SPECIES DISTRIBUTION MODELLING WITH ONLY-PRESENCE RECORDS

open access: yesTropical and Subtropical Agroecosystems, 2015
One of the central issues in ecology is the study of geographical distribution of species of flora and fauna through Species Distribution Models (SDM). Recently, scientific interest has focused on presence-only records.
Bartolo de Jesús Villar-Hernández   +1 more
doaj  

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