Results 61 to 70 of about 14,653,154 (285)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Assessing the freshwater distribution of yellow eel [PDF]

, 2008
In the global context of the decline in wild species, modeling the distribution of populations is a crucial aspect of ecological management. This can be a major challenge, especially for species, such as the European eel, that have complex life cycles ...
Lasne, Emilien, É. Lasne, P. Laffaille, Laffaille, Pascal, Laffaille P., Lasne É.   +5 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Climate Change Impacts on the Distribution of oriental beech (Fagus orientalis Lipski) in the Hyrcanian Forests of Iran [PDF]

مجله جنگل ایران, 2018
Due to global climate change, climate change in Iran is inevitable and the results of the climate studies clearly show that the Hyrcanian climate has been warmer over the past 50 years.
Hamid Taleshi, Seyed Gholamali Jalali, J Alavi, Seyed Mohsen Hosseini, Babak Naimi   +4 more
doaj  

What can community ecologists learn from species distribution models?

Ecosphere, 2021
Species distribution and ecological niche models (SDMs and ENMs) are popular tools used in a wide variety of research and conservation applications. However, their use in understanding community‐level patterns and processes is an emerging and rapidly ...
Stephen J. Murphy, Adam B. Smith
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Determining the minimal background area for species distribution models: MinBAR package

, 2021
One of the crucial choices when modelling species distributions using pseudo-absences and background approaches is the delineation of the background area to fit the model.
Traveset, Anna, Rotllán-Puig, Xavier
core   +1 more source

Chorotypes and geographic relationships among endemic species of the Transmexican Volcanic Belt, Mexico

Revista Mexicana de Biodiversidad
The Transmexican Volcanic Belt (TVB) is a complex biogeographical province characterized by several areas of endemism and high diversity of flora and fauna produced by complex geological and evolutionary processes.
Tania Escalante, Leslie Madeleine Elguea-Manrique, Perla Carolina Espíritu-Guerrero   +2 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source