Results 171 to 180 of about 13,050,965 (387)

Multi‐omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf   +10 more
wiley   +1 more source

Measurement of trace stratospheric constituents with a balloon borne laser radar [PDF]

open access: yes
The objective of this research was to measure the concentration of the stratospheric hydroxyl radical and related chemical species as a function of altitude, season, and time of day.
Heaps, William S., Mcgee, Thomas J.
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

open access: yesMolecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece   +18 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Biological control of Rubus alceifolius (Rosaceae) in La Réunion Island (Indian Ocean): from investigations of the plant to the release of the biocontrol agent Cibdela janthina (Argidae) [PDF]

open access: yes, 2011
The giant bramble (Rubus alceifolius Poir.: Rosaceae), native to Southeast Asia, is one of the most invasive plants in La Réunion. A ten year research program was launched in 1997 with three components: i) genetic diversity, ii) development strategy, and
Baret, Stéphane   +2 more
core  

Species-specific mechanisms of carcinogenesis.

open access: yesIARC scientific publications, 1992
published
Swenberg, James A.   +3 more
openaire   +2 more sources

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