Results 191 to 200 of about 748,053 (311)

Characterizing the original anti-C5 function-blocking antibody, BB5.1, for species specificity, mode of action and interactions with C5. [PDF]

Immunology, 2020
Zelek WM, Menzies GE, Brancale A, Stockinger B, Morgan BP.   +4 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Non-<i>Helicobacter pylori Helicobacters</i>, a Treatable Provocateur of Parkinson's Disease: Hypothesis, Evidence and Species Specificity. [PDF]

Int J Mol Sci
Wang W, Smith M, Ellis R, Savio A, Nevel A, Umamahesan C, Pavlidis P, Hayee BH, Taylor D, Young AH, Charlett A, Dobbs SM, Dobbs RJ.   +12 more
europepmc   +1 more source

Vitamin D-regulated Gene Expression Profiles: Species-specificity and Cell-specific Effects on Metabolism and Immunity.

Endocrinology, 2021
Dimitrov V, Barbier C, Ismailova A, Wang Y, Dmowski K, Salehi-Tabar R, Memari B, Groulx-Boivin E, White JH.   +8 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Biomimetic Analogues of the Desferrioxamine E Siderophore for PET Imaging of Invasive Aspergillosis: Targeting Properties and Species Specificity. [PDF]

J Med Chem
Mular A, Hubmann I, Petrik M, Bendova K, Neuzilova B, Aguiar M, Caballero P, Shanzer A, Kozłowski H, Haas H, Decristoforo C, Gumienna-Kontecka E.   +11 more
europepmc   +1 more source

Species specificity and intraspecific variation in the chemical profiles of <i>Heliconius</i> butterflies across a large geographic range. [PDF]

Ecol Evol, 2020
Darragh K, Montejo-Kovacevich G, Kozak KM, Morrison CR, Figueiredo CME, Ready JS, Salazar C, Linares M, Byers KJRP, Merrill RM, McMillan WO, Schulz S, Jiggins CD.   +12 more
europepmc   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Species specificity and sexual dimorphism in tooth shape among the three sympatric haplochromine species in Lake Kivu cichlids. [PDF]

Ecol Evol, 2020
Munyandamutsa P, Jere WL, Kassam D, Mtethiwa A.   +3 more
europepmc   +1 more source