Results 111 to 120 of about 29,229,093 (355)

Cell cycle regulation of a Xenopus Wee1-like kinase [PDF]

, 1995
Using a polymerase chain reaction-based strategy, we have isolated a gene encoding a Wee1-like kinase from Xenopus eggs. The recombinant Xenopus Wee1 protein efficiently phosphorylates Cdc2 exclusively on Tyr- 15 in a cyclin-dependent manner.
Coleman, Thomas R., Dunphy, William G., Mueller, Paul R.   +2 more
core  

Epigenetic regulation of brain region-specific microglia clearance activity

Nature Neuroscience, 2018
The rapid elimination of dying neurons and nonfunctional synapses in the brain is carried out by microglia, the resident myeloid cells of the brain. Here we show that microglia clearance activity in the adult brain is regionally regulated and depends on ...
Pinar Ayata, Ana Badimon, Hayley J Strasburger, M. K. Duff, Sarah E. Montgomery, Y. Loh, A. Ebert, A. Pimenova, Brianna R Ramirez, Andrew T. Chan, J. M. Sullivan, Immanuel Purushothaman, Joseph R. Scarpa, A. Goate, M. Busslinger, Li Shen, B. Losic, A. Schaefer   +17 more
semanticscholar   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Spontaneous cortical activity transiently organises into frequency specific phase-coupling networks

bioRxiv, 2017
Frequency-specific oscillations and phase-coupling of neuronal populations are essential mechanisms for the coordination of activity between brain areas during cognitive tasks.
D. Vidaurre, L. Hunt, A. Quinn, Benjamin A. E. Hunt, M. Brookes, A. Nobre, M. Woolrich   +6 more
semanticscholar   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Quantittative Analysis of Amount and Activity of Ficin in Khorasan’s Fig Tree Latex Retrieved from Different Organs of Tree in Different Seasons

Journal of Medicinal Plants, 2006
Background: The fig tree latex has been identified as a rich resource of "ficin" an enzyme protein. This enzyme has a vast application in food substances, pharmaceutical and clinical diagnosis, Fig plant can be harvested well in Khorasan province ...
O Rajabi, J Danaie Baghaki, AR Varasateh, L Jahangiri, A Baratian   +4 more
doaj  

Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner

Nature Communications, 2018
Mounting evidence suggests that neuronal activity influences myelination, potentially allowing for experience-driven modulation of neural circuitry. The degree to which neuronal activity is capable of regulating myelination at the individual axon level ...
S. Mitew, Ilan Gobius, Laura R. Fenlon, S. McDougall, David Hawkes, Y. Xing, H. Bujalka, A. Gundlach, L. Richards, T. Kilpatrick, Tobias D. Merson, B. Emery   +11 more
semanticscholar   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source