Results 131 to 140 of about 17,312,941 (313)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Live tularemia vaccine quality assessment according to test results under the mandatory certification

Биопрепараты: Профилактика, диагностика, лечение, 2018
The results of the tests for the quality assessment of live tularemia vaccine under the Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» of the Ministry of Health of the Russian Federation in 2011-2015 ...
I. V. Kasina, L. I. Raschepkin, A. A. Goryaev, S. A. Alekseeva, T. I. Nemirovskaya, A. A. Movsesyants   +5 more
doaj  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Certification of the industry reference standard for the specific activity of «BiVac polio» - live attenuated bivalent oral polio vaccine type 1 and 3

Биопрепараты: Профилактика, диагностика, лечение, 2018
The standardization and control of «BiVac polio» (live attenuated bivalent oral polio vaccine type 1 and 3) developed by M. P. Chumakov Institute of Poliomyelitis and Viral Encephalitides of the Russian Academy of Medical Sciences, called for ...
E. V. Karpova, A. D. Sangadzhieva, T. V. Mamontova, O. V. Fadeykina, R. A. Volkova, K. A. Sarkisyan, A. A. Movsesyants   +6 more
doaj  

CHARACTERISTICS OF TRYPSIN ISOLATED FROM THE INTERNAL ORGANS OF YELLOWFIN TUNA AND STABILITY IN NaCl: KARAKTERISTIK TRIPSIN YANG DIISOLASI DARI ORGAN DALAM IKAN TUNA SIRIP KUNING DAN STABILITASNYA DALAM NaCl

Jurnal Teknologi Perikanan dan Kelautan
The demand for enzymes in Indonesia is extremely high, and they are still imported from other countries. Commercial trypsin is usually extracted from the pancreas of pigs and cattle, so other alternative sources are needed from fish, namely the ...
Tati Nurhayati, Asadatun Abdullah, Fakhrina Auliya, Raden Hilman Wirayudha, Riki Kurniawan   +4 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Research on Characteristics of Irradiation Production of 63Ni with High Specific Activity

Journal of Isotopes
63Ni is an important industrial radioisotope，which has the characteristics of long half-life，moderate power density and easy to manufacture. 63Ni is a promising β radiation source with low energy.
Jian LI, Jing ZHAO, Zhihong LIU, Wei XU, Heng XIE, Lei SHI   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Optimization of fish sampling procedure for evaluating the specific activity of 137Cs, 90Sr and accumulation coefficients

Ядерна фізика та енергетика, 2016
Problem of optimization of sampling procedure for evaluating the median of specific activity and accumulation coefficients of the 137Cs and 90Sr for the populations of different species of fish lived in the pond was observed.
Yu. V. Khomutinin, V. O. Kashparov , Ukrainian Institute of Agricultural Radiology of NUBiP of Ukraine, Kyiv, Ukraine   +2 more
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