Results 161 to 170 of about 17,312,941 (313)

DEVELOPMENT OF QUALITY CONTROL SAMPLE TO ASSESS SPECIFIC ACTIVITY OF ANTI-RABIES IMMUNOGLOBULIN OBTAINED FROM EQUINE BLOOD SERUM

Разработка и регистрация лекарственных средств, 2019
The paper contains the data on the development of quality control sample (QCS) for determination of specific activity of heterologous anti-rabies immunoglobulin in neutralization test on white mice.
E. G. Abramova, O. A. Lobovikova, I. V. Shul’gina, A. V. Komissarov, L. V. Savitskaya, S. V. Generalov, M. V. Galkina, Yu. K. Gavrilova, A. V. Kochkin, A. K. Nikiforov   +9 more
doaj  

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Genomic language model for predicting enhancers and their allele-specific activity in the human genome. [PDF]

Bioinformatics
Sathian R, Dutta P, Ay F, Davuluri RV.
europepmc   +1 more source

Tinnitus-frequency specific activity and connectivity: A MEG study. [PDF]

Neuroimage Clin, 2023
Salvari V, Korth D, Paraskevopoulos E, Wollbrink A, Ivansic D, Guntinas-Lichius O, Klingner C, Pantev C, Dobel C.   +8 more
europepmc   +1 more source

Accelerometer Monitoring Duration for Reliable Estimates of Physical Activity, Sedentary Behavior, and Step Counts in Preschoolers

This study aims to establish the reliability of accelerometer-based measurements for physical activity, sedentary behavior, and step counts in preschoolers and determine the optimal monitoring duration necessary for reliable data.
Álvarez Barbosa, Francisco, Antczak, Devan, Ramos Munell, Javier, Pozo Cruz, Jesús del, Pozo Cruz, Borja del, Alfonso Rosa, Rosa Mª   +5 more
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Repurposing drugs with specific activity against L-form bacteria. [PDF]

Front Microbiol, 2023
Emami K, Banks P, Wu LJ, Errington J.
europepmc   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Quantitative determination of trace principal components with high specific activity in menotropins. [PDF]

Front Bioeng Biotechnol
Sun Y, Li H, Hu X, Luo S, Zhang X, Wang L, Li Y, Lyu P, Li J.   +8 more
europepmc   +1 more source