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Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

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Variability of specific activities and specific-activity ratios

Archives of Biochemistry and Biophysics, 1957
Abstract In studies involving the use of specific activities or specific-activity ratios, the amount of the P32 inoculum will apparently have no effect on the coefficient of variation of the results. Dilution of the biological material prior to fractionation, dilution of the digested fractions, or loss of material during digestion will lead to a rise
R L, STEARMAN, T G, WARD
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Specific Activity of Trypsin

Journal of Pharmaceutical Sciences, 1966
Trypsin has been fractionated electrophoret ically on cellulose acet ate into four tones. The lead zone, which contains the tryptic activity, was treated with specific substrate for enzyme activity and with the Lowry test for protein content. Specific activity of pure trypsin appears to be slightly greater than 8000 N.F. u./mg.
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Layer-specific interneuron activity

Science, 2017
Brain Microcircuits Somatostatin-expressing interneurons are an important group of inhibitory neurons in the brain that target and thus control the dendrites of pyramidal cells. These interneurons have recently been shown to play a role in sensorimotor integration, reinforcement encoding ...
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Institution Specific Activities

1981
Each participating center designates a data manager. This individual is responsible for submitting all study forms, responding to all data and clarification requests, and telephoning for patient entry. Specialization of this responsibility promotes efficient data collection leading to high quality therapy evaluation.
Kenneth Stanley, Jan Stjernswärd, Mary Isley   +2 more
openaire   +1 more source

Antigen-Specific B-Lymphocyte Activation

Critical Reviews in Immunology, 2003
B lymphocytes comprise a major component of the adaptive mammalian immune system, having the exclusive ability to produce and secrete immunoglobulins (Ig) of various forms (isotypes). This property alone renders B-cell activation critical to immunity, but the fully activated B cell also functions in antigen presentation and the production of a variety ...
Gail A, Bishop, Sokol A, Haxhinasto, Laura L, Stunz, Bruce S, Hostager   +3 more
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Human task‐specific somatosensory activation

Neurology, 1987
We used positron emission tomography to study normal patterns of local cortical metabolic activation induced by somatosensory stimuli. Palpation and sorting of mah-jongg tiles by textured design increased local glucose metabolic rate (lCMRgl), by 18% on average, in contralateral somatosensory cortex. A graphesthesia task gave a similar result.
M D, Ginsberg, F, Yoshii, S, Vibulsresth, J Y, Chang, R, Duara, W W, Barker, T E, Boothe   +6 more
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Active Specific Immunotherapy Against Adenocarcinomas

Cancer Investigation, 1994
(1994). Active Specific Immunotherapy Against Adenocarcinomas. Cancer Investigation: Vol. 12, No. 1, pp. 46-56.
G D, MacLean, M A, Reddish, M B, Bowen-Yacyshyn, S, Poppema, B M, Longenecker   +4 more
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