Results 71 to 80 of about 2,463,176 (288)

Cellular delivery of antibodies: effective targeted subcellular imaging and new therapeutic tool [PDF]

, 2010
It is already more than a century since the pioneering work of the Nobel Laureate Ehrlich gave birth to the side chain theory1, which helped to define antibodies and their ability to target specific biological sites.
Andrew L. Lewis, Giuseppe Battaglia, Irene Canton, Marzia Massignani, Nicholas J. Warren, Nisa Patikarnmonthon, Steven P. Armes   +6 more
core   +1 more source

Influence of anticardiolipin and anti-β2 glycoprotein I antibody cutoff values on antiphospholipid syndrome classification [PDF]

, 2019
Background: Anticardiolipin (aCL) and anti-beta 2 glycoprotein I (a beta 2GPI) immunoglobulin (Ig) G/IgM antibodies are 2 of the 3 laboratory criteria for classification of antiphospholipid syndrome (APS).
de Laat, Bas, Devreese, Katrien, Kelchtermans, Hilde, Musial, Jacek, Vanoverschelde, Laura   +4 more
core   +3 more sources

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Non-specific binding of antibodies in immunohistochemistry: Fakes and facts [PDF]

, 2011
Protocols for blocking non-specific antibody (Ab) binding in immunohistochemistry are based on rather contradictory and outdated reports. This prompted us to prove, whether non-specific Ab binding may really lead to unwanted background staining in ...
Igor Buchwalow, Markus Tiemann, Vera Samoilova, Werner Boecker   +3 more
core   +1 more source

Identification of hepatitis a virus mimotopes by phage display, antigenicity and immunogenicity [PDF]

, 2007
A phage-displayed peptide approach was used to identify ligands mimicking antigenic determinants of hepatitis A virus (HAV) for the first time. Bacteriophages displaying HAV mimotopes were isolated from a phage-display peptide library by affinity ...
Alicia Aguilar, Altschul, Arturo Talavera, Beales, Beckmann, Bosch, Burritt, Burritt, Clark, Cohen, Collins, Cuthbert, David I. Stott, de la Cruz, Delmastro, Ela M. Perez, Emini, Enshell-Seijffers, Felici, Folgori, Folgori, Frank Camacho, Gomara, Hollinger, Hoogenboon, Irving, Lemon, Lemon, Lemon, Lemon, Lemon, Lemon, Marston, Martin, Mattioli, Nainan, Neduva, Nevis Amin, Osmany G. Larralde, Partidos, Perea, Perez, Ping, Ping, Prezzi, Raiza Martinez, Reed, Sambrook, Scholfield, Stapleton, Stapleton, Stapleton, Verdaguer, Wan, Zhang   +54 more
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

A bioinformatics approach to the development of immunoassays for specified risk material in canned meat products [PDF]

A bioinformatics approach to developing antibodies to specific proteins has been evaluated for the production of antibodies to heat-processed specified risk tissues from ruminants (brain and eye tissue).
Baumgartner, S., Bremer, M.G.E.G., Danks, C., Hemetsberger, C., Lubbe, W., Reece, P., Smits, N.G.E., Stones, R., Tomkies, V.   +8 more
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Donor specific antibodies after transplantation [PDF]

Pediatric Transplantation, 2011
Platt JL, Cascalho M. Donor specific antibodies after transplantation.
Pediatr Transplantation 2011: 15: 686–690. © 2011 John Wiley & Sons A/S.Abstract: The detection of donor‐specific antibodies after organ transplantation might provide an incisive way to monitor allo‐specific immunity and predict graft outcome.
Platt, Jeffrey L., Cascalho, Marilia
openaire   +3 more sources