A gp41 MPER-specific llama VHH requires a hydrophobic CDR3 for neutralization but not for antigen recognition [PDF]
, 2013 The membrane proximal external region (MPER) of the HIV-1 glycoprotein gp41 is targeted by the broadly neutralizing antibodies 2F5 and 4E10. To date, no immunization regimen in animals or humans has produced HIV-1 neutralizing MPER-specific antibodies ...
Aasa-Chapman, Marlén M. I. +23 more
core +6 more sources
Detection of myositis-specific antibodies [PDF]
Annals of the Rheumatic Diseases, 2019 It was with much interest that we read the recent European League Against Rheumatism/American College of Rheumatology classification criteria for idiopathic inflammatory myopathies.1 These criteria include Jo-1 autoantibodies, and the authors discussed that future updates of the criteria should also include the more recently identified myositis ...
Jean-Baptiste, Vulsteke +10 more
openaire +2 more sources
Stalking influenza by vaccination with pre-fusion headless HA mini-stem. [PDF]
, 2016 Inaccuracies in prediction of circulating viral strain genotypes and the possibility of novel reassortants causing a pandemic outbreak necessitate the development of an anti-influenza vaccine with increased breadth of protection and potential for rapid ...
A Schneemann +35 more
core +2 more sources
γδ T cells affect IL-4 production and B-cell tolerance [PDF]
, 2014 γδ T cells can influence specific antibody responses. Here, we report that mice deficient in individual γδ T-cell subsets have altered levels of serum antibodies, including all major subclasses, sometimes regardless of the presence of αβ T cells.
Andrew Getahun +22 more
core +1 more source
Effect of lily flavone on OVA induced food allergy
Shipin yu jixieObjectiveThis study aimed to explore the anti-allergic effect of lily flavone.MethodsA mouse food allergy model was induced by egg allergen ovalbumin (OVA), and different doses of lily flavone were given to intervene.
JU Meiling, LU Jing
doaj +1 more source
Specific IgA antibodies in Mycoplasma pneumoniae infections
Microbiologia Medica, 2011 Mycoplasma pneumoniae is the prevalent cause of community acquired pneumonia (CAP), especially in pediatric age. M. pneumoniae infection may presents a severe pulmonary disease whose clinical picture is undistinguishable from that of other pneumotropic ...
Gino Ciarrocchi +7 more
doaj +1 more source
Recombinant Envelope-Proteins with Mutations in the Conserved Fusion Loop Allow Specific Serological Diagnosis of Dengue-Infections [PDF]
, 2015 Dengue virus (DENV) is a mosquito-borne flavivirus and a major international public health concern in many tropical and sub-tropical areas worldwide. DENV is divided into four major serotypes, and infection with one serotype leads to immunity against the
Barzon, Luisa +5 more
core +4 more sources
A toolbox of nanobodies developed and validated for use as intrabodies and nanoscale immunolabels in mammalian brain neurons. [PDF]
, 2019 Nanobodies (nAbs) are small, minimal antibodies that have distinct attributes that make them uniquely suited for certain biomedical research, diagnostic and therapeutic applications.
Dong, Jie-Xian +11 more
core
Therapeutic antibodies: current state and future trends--is a paradigm change coming soon? [PDF]
, 2008 Antibody-based therapeutics currently enjoy unprecedented success, growth in research and revenues, and recognition of their potential. It appears that the promise of the "magic bullet" has largely been realized.
Dimitrov, Dimiter S, Marks, James D
core +1 more source
Contact urticaria to giraffe hair [PDF]
, 2005 Background: Immediate-type hypersensitivity to animal proteins is a common problem in people occupationally exposed to animals. Methods: A 19-year-old female working as a voluntary zookeeper in her off-time suffered from hives on her forearms following ...
Herzinger, T. +3 more
core +1 more source