Results 111 to 120 of about 2,089,298 (305)

Diallel analysis and genetic differentiation of tropical and temperate maize inbred lines

Crop Breeding and Applied Biotechnology, 2018
This study aimed to evaluate hybrids obtained by the cross among temperate × tropical elite maize lines, and to determine the genetic diversity and population differentiation of these inbred lines.
Vania Portes Kulka, Tereza Aparecida da Silva, Rodrigo I. Contreras-Soto, Carlos Maldonado, Freddy Mora, Carlos Alberto Scapim   +5 more
doaj  

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Material properties of the heel fat pad across strain rates [PDF]

, 2016
The complex structural and material behaviour of the human heel fat pad determines the transmission of plantar loading to the lower limb across a wide range of loading scenarios; from locomotion to injurious incidents.
Bull, AMJ, Carpanen, D, Christou, A, Grigoriadis, G, Masouros, S, Newell, N   +5 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Combining ability for yield and yield-associated traits in wheat (Triticum aestivum L.)

Electronic Journal of Plant Breeding
The current breeding effort aims to develop new wheat genotypes with higher genetic potential, thereby contributing to food security. Ten wheat genotypes were crossed in a half-diallel mating design.
Afsar Ahmad1 and Rajesh Kumar Gupta2
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Concept of General and Specific Combining Ability in Relation to Diallel Crossing Systems [PDF]

Australian Journal of Biological Sciences, 1956
A detailed examination of the concept of combining ability in relation to diallel crossing systems is made. Eight different analyses aro presented. 'l'hese result from a consideration of four different diallel crossing systems together wit.h two alternative assumptions with regard to the sampling nature of tho experimental material. A numerical example
openaire   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Combining Ability for Grain Yield and Popping Expansion in Popcorn (Zea mays everta) Hybrids

Turkish Journal of Agriculture: Food Science and Technology
The poor yield and popping quality underscore the need for indigenous germplasm improvement. This study aimed to find parents with high general combining ability (GCA) and specific combining ability (SCA) for yield and popping traits.
Oloruntoba O. Olakojo, Dotun J. Ogunniya, Adewole T. Akintunde, Samuel A. Olakojo   +3 more
doaj   +1 more source