Results 91 to 100 of about 639,854 (264)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Determination of General and Specific Combining Ability of Five Upland Cotton Cultivars

Journal of Agricultural Science, 2016
<p>The present investigation was aimed to determine the general combining ability of the parental lines and specific combining ability of the hybrids respectively and also heterotic effect of F₁ hybrids for some agro-economical traits in upland cotton. Five parent genotypes viz.
Habib R. Lakho, Ayaz A. Soomro, Muhammad A. R. Rashid, Shabana Memon   +3 more
openaire   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Combining ability for yield and yield-associated traits in wheat (Triticum aestivum L.)

Electronic Journal of Plant Breeding
The current breeding effort aims to develop new wheat genotypes with higher genetic potential, thereby contributing to food security. Ten wheat genotypes were crossed in a half-diallel mating design.
Afsar Ahmad1 and Rajesh Kumar Gupta2
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Combining Ability for Grain Yield and Popping Expansion in Popcorn (Zea mays everta) Hybrids

Turkish Journal of Agriculture: Food Science and Technology
The poor yield and popping quality underscore the need for indigenous germplasm improvement. This study aimed to find parents with high general combining ability (GCA) and specific combining ability (SCA) for yield and popping traits.
Oloruntoba O. Olakojo, Dotun J. Ogunniya, Adewole T. Akintunde, Samuel A. Olakojo   +3 more
doaj   +1 more source

Heterosis and combining ability for yield and other agronomic traits in Triticale

Open Agriculture, 2018
The estimation of genetic parameters such as heterosis (Mh), heterobeltiosis (Hh), general combining ability (GCA) and specific combining ability (SCA) allows inferences about the predominant action of the genes, indicates the appropriate selection ...
Ferrari Enzo, Picca Aurora, Domínguez Rodolfo, Paccapelo Héctor   +3 more
doaj   +1 more source

General (GCA) and specific (SCA) combining abilities in sunflower

, 2000
Used in this study were 20 new Rf-lines, five A-tester lines and their 100 hybrid combinations. A large number of agronomically important traits of these genotypes have been studied. The present paper reports the results for plant height, seed yield (kg/ha), seed oil content (%), oil yield (kg/ha),'and resistance to Sclerotinia head rot. In most of the
Škorić, Dragan, Jocić, Siniša, Molnar, Igor   +2 more
openaire   +2 more sources