Results 41 to 50 of about 97,963 (258)
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
On Energy Assessment of Titanium Alloys Belt Grinding Involving Abrasive Wear Effects
Chinese Journal of Mechanical Engineering, 2023 Improved energy utilisation, precision, and quality are critical in the current trend of low-carbon green manufacturing. In this study, three abrasive belts were prepared at various wear stages and characterised quantitatively.
Mingcong Li +5 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Numerical simulation of induced cutting in deep coal [PDF]
Royal Society Open Science, 2019 Deep coal cutting is a hot research topic at present. In this paper, the cutting technology of three-drum shearer was proposed based on previous studies.
Si-fei Liu +4 more
doaj +1 more source
Mechanics & Industry, 2023 Due to the great differences in mechanical properties between hard concretion and coal, the shearer drum cutting coal and rock containing hard concretion will inevitably lead to a series of problems, such as severe load impact, increased cutting specific
Liu Xunan +4 more
doaj +1 more source
Prediction of specific cutting energy for large diameter circular saws during natural stone cutting
International Journal of Rock Mechanics and Mining Sciences, 2012 Abstract Statistical methods re-utilized for the prediction of specific cutting energy values ( SE cut ) based on the operational variables of block cutters and rock properties. Performance measurements of seven different types of block cutters were applied to six different carbonate rocks and three stone processing plants.
Yurdakul, Murat, Akdas, Hurriyet
openaire +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Nihon Kikai Gakkai ronbunshu, 2020 An evaluating equation to present the influence of thermal properties of workpiece and cutting tool on the cutting temperature is derived by the dimensional analysis.
Takashi UEDA +3 more
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source