Results 51 to 60 of about 97,963 (258)

Research and development of cutting or grinding specific energy database system for key components of typical machine tools

Jin'gangshi yu moliao moju gongcheng, 2017
Based on the existing energy consumption research, and according to the empirical relation between the material removal power and the no-load power and machining power of the machine tools, an empirical calculation model for cutting or grinding specific ...
YIN Hui, DENG Chaohui, ZHANG Hua, FU Yahui, YAN Can   +4 more
doaj  

Specific cutting energy consumption in a circular saw for Eucalyptus stands VM01 and MN463 [PDF]

CERNE, 2011
Modern technologies for continuous carbonization of Eucalyptus sp. require special care in wood cutting procedures. Choosing the right tool, cutting speeds and feed rates is important to manage time and energy consumption, both of which being critical factors in optimizing production.
Souza, Erica Moraes de, Silva, José Reinaldo Moreira da, Lima, José Tarcísio, Napoli, Alfredo, Raad, Túlio Jardim, Gontijo, Thiago Gomes   +5 more
openaire   +4 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Modeling and optimization of machining parameters in milling of INCONEL-800 super alloy considering energy, productivity, and quality using nanoparticle suspended lubrication

Measurement + Control, 2021
Inconel-800 super alloy is a newly difficult-to-cut material. To improve the cutting conditions for this metal, sustainable methods in which minimum quantity lubrication enhanced with suspended nanoparticle were employed. This work also aims to model the
Te-Ching Hsiao, Ngoc-Chien Vu, Ming-Chang Tsai, Xuan-Phuong Dang, Shyh-Chour Huang   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Dynamic Cutting Properties of Miscanthus (giganteus) Stems Using an Impact Tester

AgriEngineering
Miscanthus (giganteus) is a relatively new energy crop. Its mechanical properties are important for the design and modification of harvesting and processing machines or equipment.
Zhankozy Toleu, Jude Liu
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Cutting energy required during the mechanical processing of wood species at different drying stages

Maderas: Ciencia y Tecnología, 2020
The aim of this study was to know the variation profile of the specific energy consumption required to cut woods with varying densities and moisture contents.
Taiane Oliveira Guedes, José Reinaldo Moreira da Silva, Paulo Ricardo Gherardi Hein, Silvia Costa Ferreira   +3 more
doaj  

Influence of pick working angle on cutting performance of auger miner’s aiguille

Advances in Mechanical Engineering, 2015
To study the influence of pick working angles on cutting performance of auger miner’s aiguille, aiguilles with different pick working angles were developed and their performance were tested on coal cutting test-bed.
Lin Fu, Changlong Du, Jianping Li, Kehong Zheng   +3 more
doaj   +1 more source