Results 71 to 80 of about 100,934 (288)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Cutting energy required during the mechanical processing of wood species at different drying stages

Maderas: Ciencia y Tecnología, 2020
The aim of this study was to know the variation profile of the specific energy consumption required to cut woods with varying densities and moisture contents.
Taiane Oliveira Guedes, José Reinaldo Moreira da Silva, Paulo Ricardo Gherardi Hein, Silvia Costa Ferreira   +3 more
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Effect of moisture content on specific cutting energy consumption in Corymbia citriodora and Eucalyptus urophylla woods

, 2017
The effects of various moisture conditions on the specific cutting energy of the longitudinal cut (90º-0º) in Eucalyptus urophylla S.T. Blake and Corymbia citriodora Hill & Johnson were studied.
Nascimento, Débora Fernanda Reis, de Lima Melo, Luiz Eduardo, Napoli, Alfredo, Paulo Fernando Trugilho, Moreira da Silva, Jose Reinaldo, Luiz Eduardo de Lima Melo, José Reinaldo Moreira da Silva, Débora Fernanda Reis Nascimento, Trugilho, Paulo Fernando, Alfredo Napoli   +9 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Considerations for Discrete Element Modeling of Rock Cutting [PDF]

, 2013
This study attempts to build a framework within the Discrete Element Method (DEM) to produce a reliable predictive tool in rock cutting applications, such that the cutting forces and fragmentation process are reasonably estimated. The study is limited to
Mendoza Rizo, Jorge Alejandro
core  

Effect of various knife type, cutting angle and speed on cutting force and energy of grape cane [PDF]

, 2019
In this study, some cutting and energy properties of canes of local grapes varieties Okuzgozu (Vitis vinifera L. cv.) were determineddepend on knife type, cutting angle and cutting speed during the spring pruning in 2018.
Sessiz, Abdullah, Pekitkan, Fatih Göksel, Eliçin, Ahmet Konuralp   +2 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Comparative study of rotational and longitudinal turning: Energy efficiency and surface roughness in machining normalized medium-carbon steel [PDF]

FME Transactions
This study compares rotational and longitudinal turning during the machining of normalized medium-carbon steel. The aim is to evaluate differences in energy efficiency and surface quality.
Sztankovics István, Rodić Dragan
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source