Results 71 to 80 of about 13,372,123 (291)

Modeling and optimization of machining parameters in milling of INCONEL-800 super alloy considering energy, productivity, and quality using nanoparticle suspended lubrication

Measurement + Control, 2021
Inconel-800 super alloy is a newly difficult-to-cut material. To improve the cutting conditions for this metal, sustainable methods in which minimum quantity lubrication enhanced with suspended nanoparticle were employed. This work also aims to model the
Te-Ching Hsiao, Ngoc-Chien Vu, Ming-Chang Tsai, Xuan-Phuong Dang, Shyh-Chour Huang   +4 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Dynamic Cutting Properties of Miscanthus (giganteus) Stems Using an Impact Tester

AgriEngineering
Miscanthus (giganteus) is a relatively new energy crop. Its mechanical properties are important for the design and modification of harvesting and processing machines or equipment.
Zhankozy Toleu, Jude Liu
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Cutting energy required during the mechanical processing of wood species at different drying stages

Maderas: Ciencia y Tecnología, 2020
The aim of this study was to know the variation profile of the specific energy consumption required to cut woods with varying densities and moisture contents.
Taiane Oliveira Guedes, José Reinaldo Moreira da Silva, Paulo Ricardo Gherardi Hein, Silvia Costa Ferreira   +3 more
doaj  

Mechanistic Cutting Force Model and Specific Cutting Energy Prediction for Modulation Assisted Machining

Procedia Manufacturing, 2020
This paper presents a mechanistic model for analytical cutting force and specific energy prediction for modulation assisted turning. Kinematics of the process is used to analyze the cut surface topography and derive the uncut chip thickness variation for
Bora Eren, Burak Sencer
semanticscholar   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Fundamental Study into the Mechanics of Material Removal in Rock Cutting [PDF]

The objective of this work was to understand the mechanics of material removal during rock cutting. The exact nature of the failure of the rock material at the tool tip was investigated using a single cutting tooth test rig coupled with high speed ...
Aresh, Balaji
core  

Evalaution and optimization of laser cutting parameters for plywood materials [PDF]

, 2013
Laser process parameters influence greatly the width of kerfs and quality of the cut edges. This article reports experiments on the laser plywood-cutting performance of a CW 1.5 kW CO2¬ Rofin laser, based on design of experiments (DOE).
Alrashed, K., Olabi, Abdul-Ghani, Rossini, Nicola, Eltawahni, Hayat, Dassisti, Michele, Aldaham, T., Benyounis, Khaled, Olabi AG, Eltawahni HA, Rossini NS, Aldaham, TA, Benyounis KY, Alrashed, K   +12 more
core   +2 more sources

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source