Results 61 to 70 of about 1,763,581 (219)

Calculation of critical flow depth using method of algebraic inequality

Journal of Hydrology and Hydromechanics, 2018
To calculate the critical depth and the least specific energy of steady non-uniform flows in open channels, one has to solve the polynomial equations. Sometimes, the polynomial equations are too difficult to get them solved.
Cheng Tiejie, Wang Jun, Sui Jueyi
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Analysis of Roadheader for Breaking Rock Containing Holes under Confining Pressures

Energies, 2017
Deep underground mines have high energy consumption due to the need to overcome the confining pressure. This study investigates the characteristics of the roadheader used for breaking rock containing a different number and size of holes under different ...
Zenghui Liu, Changlong Du, Hongxiang Jiang, Kai Liu   +3 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

On the Energy Storage Capacity and Design Optimization of Compound Flywheel Rotors with Prestressed Hyperbolic Disks [PDF]

Journal of Applied and Computational Mechanics
Flywheels used for energy storage may be assembled by press fitting or bonding of concentric rotor parts. During operation, each part is subjected to a superposition of stress fields associated with centrifugal loading and with contact at the component ...
Sutham Arun, Wichaphon Fakkaew, Chakkapong Chamroon, Matthew Cole   +3 more
doaj   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Biofuel–Electric Hybrid Aircraft Application—A Way to Reduce Carbon Emissions in Aviation

Aerospace
As global warming intensifies, the world is increasingly concerned about carbon emissions. As an important industry that affects carbon emissions, the air transportation industry takes on the important task of energy saving and emission reduction.
Shengfei Dong, Zehua Song, Zheyi Meng, Ziyu Liu   +3 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source