Results 111 to 120 of about 13,252,850 (343)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Nonextensive Statistics in Nanoscopic Quantum Dots
NanomaterialsNanoscopic quantum dots exhibit discrete energy spectra and size- and shape-dependent thermal properties that cannot always be adequately described within the conventional Boltzmann–Gibbs statistical framework.
John A. Gil-Corrales +2 more
doaj +1 more source
, 2006 We simulate the improved three-dimensional two-component phi^4 model on the simple cubic lattice in the low and the high temperature phase for reduced temperatures down to |T-T_c|/T_c \approx 0.0017 on lattices of a size up to 350^3.
Ahlers G +7 more
core +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Reentrant classicality of a damped system
, 2013 For a free particle, the coupling to its environment can be the relevant mechanism to induce quantum behavior as the temperature is lowered. We study general linear environments with a spectral density proportional to {\omega}^s at low frequencies and ...
Ingold, Gert-Ludwig +2 more
core +1 more source
Molecular dynamics simulation of the specific heat capacity of water-Cu nanofluids
International Nano Letters, 2013 This paper presents molecular dynamics (MD) modeling for calculating the specific heat of nanofluids containing copper nanoparticles. The Cu nanoparticles with 2-nm diameter were considered to be dispersed in water as base liquid.
A. Rajabpour +3 more
semanticscholar +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Atom Indonesia, 2019 This work investigated the crystal structure, resistivity and specific heat of La0.41Ca0.59Mn1-xCuxO3 with x = 0.06 and 0.15. The samples were prepared by a solid reaction method and in milling with high energy milling (HEM) of 700 rpm for ten hours ...
Y.E. Gunanto +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Frontiers in Chemistry, 2018 Negative thermal expansion (NTE) and magnetic properties were investigated for antiperovskite Ga1−xCrxN0.83Mn3 compounds. As x increases, the temperature span (ΔT) of NTE related with Γ5g antiferromagnetic (AFM) order is expanded and shifted to lower ...
Xinge Guo +10 more
doaj +1 more source