Results 101 to 110 of about 7,347,069 (300)

Correlation of polygenic risk score and clinical phenotype in patients with genetic generalized epilepsy

Epilepsia, EarlyView.
Abstract Objective The polygenic risk score (PRS) for individuals with genetic generalized epilepsy (GGE) quantifies the common risk variants in genes identified in genome‐wide association studies. We hypothesized that the phenotype of GGE patients differs based on their GGE PRS. Methods We identified participants with highest (n = 59) versus lowest (n 
Sophie von Brauchitsch, Nils Hartung, Robin A. Karge, Bobby Koeleman, Samuel F. Berkovic, Danielle M. Andrade, Francesca Bisulli, Antonio Gambardella, Renzo Guerrini, Ingrid E. Scheffer, Ingo Helbig, Wolfram S. Kunz, Holger Lerche, Hiltrud Muhle, Christian Boßelmann, Savvas S. Papacostas, Mark I. Rees, Sanjay M. Sisodiya, Pasquale Striano, Lynnette Sadleir, Yvonne Weber, Dennis Lal, Costin Leu, Philipp S. Reif, Stefan Wolking, Felix Rosenow, Karl Martin Klein, for the Epi25 Collaborative   +27 more
wiley   +1 more source

Recombinant major urinary proteins of the mouse in specific IgE and IgG testing [PDF]

, 2007
Background: Recombinant allergens are preferred over natural allergen extracts in measuring antibodies. We tested the use of recombinant variants of the major mouse allergen Mus m 1 in detection of mouse-specific antibodies in sera of laboratory animal ...
van der Zee, JS, Chapman, Martin D., Chapman, MD, Matsui, EC, Krop, EJ, van der Zee, Jaring S., Stone, Martin J., Aalberse, Rob C., Matsui, Elizabeth C., Stone, MJ, Krop, Esmeralda J. M., Aalberse, RC, Gerber, Peter, Gerber, P, Sharrow, Scott D., Sharrow, SD   +15 more
core   +2 more sources

Epilepsy syndromes classification

Epilepsia Open, EarlyView.
Abstract Epilepsy syndromes are distinct electroclinical entities which have been recently defined by the International League Against Epilepsy Nosology and Definitions Task Force. Each syndrome is associated with “a characteristic cluster of clinical and EEG features, often supported by specific etiologic findings”.
Elaine C. Wirrell, Nicola Specchio, Rima Nabbout, Phillip L. Pearl, Kate Riney   +4 more
wiley   +1 more source

Total IgE and allergen-specific IgE and IgG antibody levels in sera of atopic dermatitis affected and non-affected Labrador- and Golden retrievers

, 2012
Canine atopic dermatitis (CAD) is an allergic skin disease associated with IgE and IgG antibodies (Ab) to environmental allergens. The aim of this study was to determine which other factors influence serum Ab levels in CAD-affected and non-affected dogs ...
Favrot, Claude, Bergvall, Kerstin, Lauber, Beatrice, Roosje, P, Tengvall, Katarina,, Lauber, B, Leeb, T, Roosje, Petra, Tengvall, K, Marti, E, Marti, Eliane Isabelle, Meury, S, Doherr, Marcus G, Favrot, C, Meury, Sabrina, Tengvall, Katarina, Molitor, Vivianne, Leeb, Tosso, Marti, Eliane, Molitor, V, Doherr, M G, Bergvall, K   +21 more
core   +1 more source

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

Genetic testing practices across European epilepsy centers: An ERN EpiCARE survey

Epilepsia Open, EarlyView.
Abstract Objective Genetic testing plays an increasing role in the diagnostic pathway for rare and complex epilepsies. However, significant heterogeneity persists in access, implementation, and interpretation across Europe. This study aimed to assess genetic testing practices, accessibility, and challenges across expert epilepsy centers within the ...
Sébile Tchaicha, Johanna Van Hulle, Eva Brilstra, Andreas Brunklaus, Gaetano Cantalupo, Martin Geroldinger, Amy McTague, Reetta Kälviäinen, Eulalia Turón‐Viñas, Alexis Arzimanoglou, Rikke S. Møller, Rima Nabbout   +11 more
wiley   +1 more source

The genetic architecture of epilepsy across molecular mechanisms and clinical heterogeneity

Epilepsia Open, EarlyView.
Abstract Epilepsy comprises a highly heterogeneous group of neurological disorders unified by a persistent predisposition to recurrent seizures, yet driven by remarkably diverse genetic, molecular, and network‐level mechanisms. Advances in genomic technologies have revealed that epilepsy arises from a multilayered genetic architecture encompassing rare
Mohammad Reza Seyedtaghia, Jina Babanzadeh, Marcello Scala, Lorenzo Perilli, Pasquale Striano   +4 more
wiley   +1 more source

Specific IgE to recombinant allergens (rBetv1 and rBetv2) and apple allergy in patients with pollinosis

Allergology International, 1999
The presence of IgE antibodies to the allergens rBetvl and rBetv2 was investigated in the sera of 99 patients with specific IgE to apple extract by comparing a group of 43 patients who had oral allergy syndrome (OAS) after ingestion of apple with a group
R.E. Rossi, G. Monasterolo, D. Operti, R. Operti   +3 more
doaj   +1 more source

Electroclinical classification of idiopathic generalized epilepsy syndromes at initial evaluation: A prospective multicenter study

Epilepsia Open, EarlyView.
Abstract Objective To determine the extent to which electroclinical information available at initial evaluation allows classification of idiopathic generalized epilepsy (IGE) syndromes, and to assess the contributions of seizure semiology and age at seizure onset to early syndromic diagnosis.
Omar Nawfal, Heba Samara, Wassim Nasreddine, Fatima Jaafar, Mahasen Reda, Tarek Halabi, Ahmad Beydoun   +6 more
wiley   +1 more source

The prevalence and identity of Chlamydia-specific IgE in children with asthma and other chronic respiratory symptoms

Respiratory Research, 2012
Background Recent studies have confirmed the presence of viable Chlamydia in the bronchoalveolar lavage (BAL) fluid of pediatric patients with airway hyperresponsiveness. While specific IgG and IgM responses to C.
Patel Katir K, Anderson Erica, Salva Paul S, Webley Wilmore C   +3 more
doaj   +1 more source