Results 101 to 110 of about 631,893 (306)
Advanced Science, EarlyView.Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley +1 more source
GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy
Advanced Science, EarlyView.Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu +11 more
wiley +1 more source
Education SciencesThe differences in the math learning process and the underlying cognitive skills of students with a mathematical learning disability and those who are low achieving in math are important to consider when supporting their learning.
Triin Kivirähk-Koor, Evelyn Kiive
doaj +1 more source
Evaluation of reading skills and Specific Learning Disability symptoms in Attention Deficit Hyperactivity Disorder [PDF]
Klinik Psikoloji Dergisi, 2018 Intelligence tests, symptom screening tests and reading tests are widely used in the evaluation of children who are referred to the clinic with learning difficulties and attention problems.
Cihat Çelik +3 more
doaj
, 2006 [Excerpt] he transition from youth to adulthood is challenging for almost every young person. This is particularly true for young people with disabilities.
National Center on Workforce and Disability/Youth
core +1 more source
Advanced Science, EarlyView.ABSTRACT Base editors enable precise genome modification and have emerged as a promising therapeutic approach for correcting diseases caused by single‐nucleotide variants. While the current efficient version of adenine base editors (ABEs), such as ABE8e, exhibits exceptional efficiency for A‐to‐G conversions, their clinical translation is hindered by ...
Jiawei Yao +12 more
wiley +1 more source
Advanced Science, EarlyView.Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska +14 more
wiley +1 more source
Advanced Science, EarlyView.When a master transcription factor (TF) is lost, bacteria can rapidly rewire gene regulatory networks by co‐opting related regulators. Using experimental evolution in Pseudomonas fluorescens, we show that TF promiscuity (low‐level, non‐cognate binding) provides the raw material for rewiring. Successful co‐option follows a predictable hierarchy governed
Tiffany B. Taylor, Alan M. Rice
wiley +1 more source
Specific Learning Disability from the Perspective of Preschool Teachers: Symptoms and What to Do
Educational Academic ResearchSpecific Learning Disability (SLD) is a type of special needs that can be diagnosed in primary school. However, research shows that there are some symptoms that are reported to be present in the pre-school period in the spatial semantic processes, in the
Cemile Nur Çam, Dila Nur Yazıcı
doaj +1 more source
An aspect of the Japanese language in relation to dyslexia : a thesis presented in partial fulfilment of the requirement for the degree of Master of Arts in Japanese at Massey University [PDF]
, 1987 These studies were conducted to examine the processing of two kinds of Japanese orthography, namely, kanji and hiragana by a group of dyslexic Subjects and Subjects in a control group of similar age, in order to ascertain the effectiveness of hemispheric
Roberts, Joan Gladys
core