Results 51 to 60 of about 338,311 (289)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Construction and screening of a pea root cDNA library [PDF]

, 1988
A cDNA library was synthesized using poly(A)(^+) RNA purified from the total RNA from roots of pea (Pisum sativum L.). Ten representative clones encoding abundant root proteins were isolated from the library after screening using colony hybridization ...
Choy, Andy Kwan Yan
core  

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Responses of belowground fine root biomass and morphology in Robinia pseudoacacia L. plantations to aboveground environmental factors

Global Ecology and Conservation
The adaptation of fine roots to a variety of environmental conditions is crucial for promoting the growth and long-term survival of forest trees. To achieve sustainable forest ecology management requires a comprehensive understanding of the intricate ...
Yonghan Feng, Xiang Sui, Jie Tang, Rui Liu, Xile Ling, Wenjun Liang, Xi Wei   +6 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Fine root morphological characteristics and biomass distribution characteristics of different artificial forests in coastal salt land and their influencing factors

Frontiers in Plant Science
To elucidate the ecological adaptations of fine root morphological traits and biomass in tree species with different life forms to coastal saline soil, five species (Robinia pseudoacacia(RP), Sapium sebiferum(SA), Salix matsudana(SM), Quercus virginiana ...
Zhibao Wang, Jing Liang, Hong Jiang, Xiangbin Gao, Shouchao Yu, Chuanjie Zhou, Yuwei Guo   +6 more
doaj   +1 more source

Genotypic Variation in Response of Rainfed Lowland Rice to Drought and Rewatering

Plant Production Science, 2000
Genotypic variation in the root system is a potential source for improving drought tolerance of rainfed lowland rice (Oryza sativa L.). Our work aimed at characterizing both constitutive root traits (those present under well -watered conditions) and ...
Tahere Azhiri- Sigari, Akira Yamauchi, Akihiko Kamoshita, Len J. Wade   +3 more
doaj   +1 more source