Results 151 to 160 of about 4,678,205 (343)

Coexistence of critical sensitivity and subcritical specificity can yield optimal population coding

, 2017
The vicinity of phase transitions selectively amplifies weak stimuli, yielding optimal sensitivity to distinguish external input. Along with this enhanced sensitivity, enhanced levels of fluctuations at criticality reduce the specificity of the response.
Gollo, Leonardo L.
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Banana lectin (BanLec) induces non-specific activation of basophils and mast cells in atopic subjects [PDF]

, 2018
N. Krithika, Siddanakoppalu N. Pramod, P A Mahesh, Yeldur P. Venkatesh   +3 more
openalex   +1 more source

Specificity of aequorin luminescence to calcium [PDF]

The presence of Pb(++), Co(++), Cu(++), and Cd(++), each of which possesses a certain luminescence-triggering activity of aequorin, potentially interferes with the specificity of the aequorin luminescence response to Ca(++).
Johnson, F. H., Shimomura, O.
core   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Liver Specific Protein—How Specific?

Gastroenterology, 1980
I G, McFarlane, A L, Eddleston, R, Williams   +2 more
openaire   +2 more sources

The N-Terminal Transactivation Domain Confers Target Gene Specificity of Hypoxia-inducible Factors HIF-1α and HIF-2α

, 2007
Cheng‐Jun Hu, Aneesa Sataur, Liyi Wang, Hongqing Chen, M. Celeste Simon   +4 more
openalex   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Sensitivity and specificity of the lipoarabinomannan test compared to GeneXpert in urine samples for tuberculosis diagnosis

Current Biomedicine
Background Mycobacterium tuberculosis (MTB) is the causative agent of tuberculosis (TB), primarily affecting lung tissue but also capable of infecting pleura, lymph nodes, bones, and other extrapulmonary sites.
Danni Irawan, Zuri Rismiarti, Acep Tantan, Fusvita Merdekawati   +3 more
doaj   +1 more source

Secretion of the Adipocyte-Specific Secretory Protein Adiponectin Critically Depends on Thiol-Mediated Protein Retention

, 2007
Zhao V. Wang, Todd Schraw, Jayoung Kim, Tayeba Khan, Michael W. Rajala, Antonia Follenzi, Philipp E. Scherer   +6 more
openalex   +1 more source