Results 11 to 20 of about 2,843,371 (243)

Characterization of the Contributions of Hydration in Protein-DNA Specificity via Structurally Conserved ETS Family Transcription Factors PU.1 and Ets-1 [PDF]

, 2023
Protein-DNA interactions involve a redistribution of conformational dynamics and hydration properties. As a model DNA-binding protein, structural and thermodynamic studies have shown that ETS transcription factor PU.1 DNA selection is dependent on ...
Albrecht, Amanda V
core   +1 more source

Diverse physiological functions for dual-specificity MAP kinase phosphatases [PDF]

, 2006
A structurally distinct subfamily of ten dual-specificity (Thr/Tyr) protein phosphatases is responsible for the regulated dephosphorylation and inactivation of mitogen-activated protein kinase (MAPK) family members in mammals.
Keyse, Stephen M, Dickinson, Robin J
core   +1 more source

Evaluation of diversity, specialization, and gene specificity in transcriptomes [PDF]

, 2009
The transcriptome is a set of genes transcribed in a given tissue under specific conditions and can be characterized by a list of genes with their corresponding frequencies of transcription.
Humberto Reyes-Valdés, Octavio Martinez, Humberto Reyes-Valdés   +2 more
core   +1 more source

Screening of DUB activity and specificity by MALDI-TOF mass spectrometry [PDF]

, 2014
Deubiquitylases (DUBs) are key regulators of the ubiquitin system which cleave ubiquitin moieties from proteins and polyubiquitin chains. Several DUBs have been implicated in various diseases and are attractive drug targets. We have developed a sensitive
Virdee, Satpal; id_orcid, Gray, Nathanael, Trost, Matthias, Ritorto, Maria Stella, Gray, Nathanael S., Alessi, Dario R., Perez-Oliva, Ana B., Wood, Nicola T., Alessi, Dario R.; id_orcid, Knebel, Axel, Buhrlage, Sara J., Ewan, Richard, Wightman, Melanie, Morrice, Nicholas A., Virdee, Satpal, Kelly, Sharon M.   +15 more
core   +1 more source

Additional file 2 of Alternative approaches to identify core bacteria in Fucus distichus microbiome and assess their distribution and host-specificity

, 2022
Additional file 2. Supplementary Table 2 showing overlapping indicator ASVs of F. distichus on Calvert Island across sampling events and their overall specificity to determine core taxa. In step2, F.
Laura Wegener Parfrey (9905826), Jungsoo Park (5073371), Geneviève Lajoie (2930004), Katherine Davis (302610)   +3 more
core   +1 more source

Low specificity of determine HIV1/2 RDT using whole blood in south west Tanzania [PDF]

, 2012
Objective: To evaluate the diagnostic performance of two rapid detection tests (RDTs) for HIV 1/2 in plasma and in whole blood samples. Methods: More than 15,000 study subjects above the age of two years participated in two rounds of a cohort study to ...
Geldmacher Christof, Petra Clowes, Elmar Saathoff, Leonard Maboko, Wolfram Mwalongo, Clowes, Petra, Hoelscher, Michael, Kroidl, Arne L., Geldmacher, Christof, Michael Hoelscher, Arne L Kroidl, Kroidl Arne L., Hoelscher Michael, Harun Machibya, Kroidl, Inge, Machibya Harun, Machibya, Harun, Saathoff, Elmar, Inge Kroidl, Maganga, Lucas, Kroidl Inge, Maganga Lucas, Mwalongo Wolfram, Christof Geldmacher, Maboko Leonard, Mwalongo, Wolfram, Saathoff Elmar, Maboko, Leonard, Lucas Maganga, Clowes Petra   +29 more
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Sensitivity And Specificity of FEF25–75/Forced Vital Capacity for Diagnosing Restrictive Lung Disease [PDF]

, 2023
Introduction and objective: The role of spirometry in the diagnosis of restrictive lung diseases is unclear. This study investigated the sensitivity and specificity of the forced expiratory flow 25–75 (FEF25–75)/forced vital capacity (FVC) parameter in ...
Fateme Ziamanesh, Mohamad Reza Tarkhorani, Maryam Edalatifard, Besharat Rahimi, Hosein Kazemi Zadeh   +4 more
core   +1 more source

Sequence Motifs in MADS Transcription Factors Responsible for Specificity and Diversification of Protein-Protein Interaction [PDF]

, 2010
Protein sequences encompass tertiary structures and contain information about specific molecular interactions, which in turn determine biological functions of proteins.
Angenent, G.C., Martijn Fiers, Roeland C H J van Ham, Roeland C. H. J. van Ham, Morabito Giuseppa, Ham, R.C.H.J., van, Aalt D J van Dijk, Angenent Gerco C., Immink, R.G.H., Richard G H Immink, van Dijk Aalt D. J., Morabito, G., van Ham Roeland C. H. J., Dijk, A.D.J., van, Fiers, M.A., Richard G. H. Immink, Giuseppa Morabito, Aalt D. J. van Dijk, Immink Richard G. H., Gerco C Angenent, Gerco C. Angenent, Fiers Martijn   +21 more
core   +2 more sources

Font Specificity [PDF]

, 2019
We explore the concept of ''image specificity'' for fonts and introduce the notion of ''font specificity''. The idea is that a font that elicits consistent descriptions from different people are more ''specific''.
Lau, Manfred, Power, Luther
core   +1 more source

Synthesis and Biological Evaluation of Novel C-28 Chloroacetamide-Modified Ursolic Acid Derivatives as Antibacterial Agents

Microorganisms
The escalating crisis of bacterial antimicrobial resistance necessitates the discovery of novel antibacterial agents with distinct mechanisms of action. Ursolic acid (UA), a naturally abundant pentacyclic triterpenoid, serves as a promising scaffold for ...
Nan Cai, Tian Luan, Junchao Zhang, Ning Li, Xiu Zhang, Peng Gao, Jiaxuan Li, Hongyu Zhan, Fanhao Meng, Dajun Zhang   +9 more
doaj   +1 more source