Results 51 to 60 of about 4,654,801 (342)

Predicting Transcription Factor Specificity with All-Atom Models [PDF]

, 2008
The binding of a transcription factor (TF) to a DNA operator site can initiate or repress the expression of a gene. Computational prediction of sites recognized by a TF has traditionally relied upon knowledge of several cognate sites, rather than an ab ...
Arvidson, Benos, Blattner, Djordjevic, Donald, Endres, Endres, Foat, Glasfeld, He, Humphrey, Ingraham, Kalodimos, Kazakov, Kinney, Kullback, Lafontaine, Leonid A. Mirny, Liu, Lu, MacKerell, Maerkl, Man, Mehran Kardar, Meng, Mironov, Morozov, Onufriev, Paillard, Paillard, Peter Virnau, Pérez, Sahand J. Rahi, Schumacher, von Hippel, Wang   +35 more
core   +3 more sources

Specificity Distinctions

Journal of Semantics, 2001
This paper is concerned with semantic noun phrase typology, focusing on the question of how to draw fine-grained distinctions necessary for an accurate account of natural language phenomena. In the extensive literature on this topic, the most commonly encountered parameters of classification concern the semantic type of the denotation of the noun ...
openaire   +3 more sources

Nutritional and Behavioral Intervention for Long‐Term Childhood Acute Leukemia Survivors With Metabolic Syndrome

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Metabolic syndrome (MetS) is a common complication in survivors of childhood acute lymphoblastic and myeloid leukemia (AL), and a major risk factor for premature cardiovascular disease, type‐2‐diabetes, and metabolic dysfunction‐associated steatotic liver disease (MASLD).
Visentin Sandrine, Béliard Sophie, Renard Cécile, Caussy Cyrielle, Hamidou Zeinab, Romano David, Gacem Mélanie, Petit Arnaud, Saultier Paul, Borentain Patrick, Michel Gérard   +10 more
wiley   +1 more source

Constraints on the position and interpretation of bare singular indefinites in Russian

Linguistica, 2016
In this paper, I discuss the distribution of bare singular indefinite nominals in Russian. I argue that these nominal phrases are full-fledged indefinites and can have both specific and non-specific indefinite interpretations.
Olga Borik
doaj   +1 more source

Selectivity and specificity: pros and cons in sensing [PDF]

, 2016
Sensing using specific and selective receptors provides two very different but complementary strategies. This Sensor Issues article will discuss the merits and challenges of specific sensors, and selective sensors based on synthetic arrays.
Peveler, William J., Rotello, Vincent M., Yazdani, Mahdieh   +2 more
core   +2 more sources

RT‐PCR–Based Detection of Bone Marrow Involvement in Ewing Sarcoma: Diagnostic Validity and Prognostic Relevance

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background In Ewing sarcoma (EwS), metastases, including those to bone marrow (BM), are the main factors influencing prognosis. Although reverse transcription polymerase chain reaction (RT‐PCR) offers greater sensitivity, the current EWING protocol defines BM metastases solely using light microscopic detection.
Thanh Pham, Andreas Ranft, Victor Rechl, Susanne Jabar, Wolfgang Hartmann, Kim Falkenberg, Heribert Jürgens, Norbert Graf, Torsten Keßler, Markus Metzler, Thomas Klingebiel, Thorsten Simon, Martin Benesch, Uta Dirksen   +13 more
wiley   +1 more source

Substrate specificity of amine oxidase [PDF]

, 1943
The tyramine oxidase activity of liver extracts found by Hare (1), the aliphatic amine oxidase activity of brain, kidney, and liver extracts observed by Pugh and Quastel (2), and the adrenalin oxidase activity of similar extracts noted by Blaschko ...
Alles, Gordon A., Heegaard, Erik V.
core  

Domain Agnostic Real-Valued Specificity Prediction

, 2018
Sentence specificity quantifies the level of detail in a sentence, characterizing the organization of information in discourse. While this information is useful for many downstream applications, specificity prediction systems predict very coarse labels ...
Durrett, Greg, Ko, Wei-Jen, Li, Junyi Jessy   +2 more
core   +1 more source

Safety and Efficacy of Anticoagulation Therapy in Paediatric Patients With Solid Tumours or Lymphomas at Risk of Thrombocytopenia: A Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Patients with solid tumours or lymphomas have an increased risk of thromboembolism (TE) and thrombocytopenia. Evidence‐based strategies for anticoagulation therapy (ACT) for patients with thrombocytopenia are limited. We examined the impact of thrombocytopenia on ACT administration and bleeding incidence in children with solid ...
Andrés Felipe Fajardo, Katherine Talpin, Bishal Harry, Uma H. Athale, Anthony K. C. Chan, Mihir D. Bhatt   +5 more
wiley   +1 more source

The conformation of the nSrc specificity-determining loop in the Src SH3 domain is modulated by a WX conserved sequence motif found in SH3 domains

Frontiers in Molecular Biosciences
Cellular signaling networks are modulated by multiple protein-protein interaction domains that coordinate extracellular inputs and processes to regulate cellular processes. Several of these domains recognize short linear motifs, or SLiMs, which are often
Frederick Longshore-Neate, Caroline Ceravolo, Cole Masuga, Elise F. Tahti, Jadon M. Blount, Sarah N. Smith, Jeanine F. Amacher   +6 more
doaj   +1 more source