Results 61 to 70 of about 2,535,115 (299)

A domain-specific language for the specification of UCON policies

Journal of Information Security and Applications, 2022
Ministerio de Ciencia e Innovación LOCOSS - PID2020-114615RB ...
Reina Quintero, Antonia M., Pérez, Salvador Martínez, Varela-Vaca, Ángel Jesús, López, María Teresa Gómez, Cabot, Jordi   +4 more
openaire   +4 more sources

Time Toxicity in Wilms Tumor: Quantifying the Burden of Healthcare Interaction in the First Year After Diagnosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook, Veerain Gupta, Nicholas J. Clark, Vijay Rings, Lauren E. Corona, Douglass B. Clayton, Daniel J. Benedetti   +6 more
wiley   +1 more source

Sensitivity And Specificity of FEF25–75/Forced Vital Capacity for Diagnosing Restrictive Lung Disease [PDF]

, 2023
Introduction and objective: The role of spirometry in the diagnosis of restrictive lung diseases is unclear. This study investigated the sensitivity and specificity of the forced expiratory flow 25–75 (FEF25–75)/forced vital capacity (FVC) parameter in ...
Fateme Ziamanesh, Mohamad Reza Tarkhorani, Maryam Edalatifard, Besharat Rahimi, Hosein Kazemi Zadeh   +4 more
core   +1 more source

Leveraging the crosstalk between cGAS-STING and pyroptosis by nanomedicine to enhance antitumor immunity

Journal of Nanobiotechnology
The cGAS-STING pathway and pyroptosis represent two potent immunostimulatory mechanisms with immense potential for cancer therapy. cGAS-STING activation drives type I interferon production and dendritic cell maturation, while pyroptosis, a form of ...
Yumin Wang, Jinxia Chen, Xuan Zhang, Zhenhua Ji, Na Zhang, Ning Li, Xiu Zhang, Shuang Zhao, Chunfei Li, Kerui Shi, Erdan Wang, Yuzi Jin   +11 more
doaj   +1 more source

Heterogeneity in the Global Practice of Central Nervous System Staging in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) is assessed by cell counting and cytomorphology from cerebrospinal fluid (CSF) and is used for treatment stratification worldwide. The ratio of “CNS2” patients in clinical trials ranges from 3% to 40%, with unclear prognostic significance ...
Laura Almási, Bernadett Borbála Huszti, Gábor Barna, Marko Kavcic, Janez Jazbec, Lennart Lenk, Vera Münch, Sophia Polychronopoulou, Ágnes Márk, Maria Thastrup, Lüder H. Meyer, Kjeld Schmiegelow, Cornelia Eckert, Christina Halsey, Dániel J. Erdélyi   +14 more
wiley   +1 more source

Sequence Motifs in MADS Transcription Factors Responsible for Specificity and Diversification of Protein-Protein Interaction

, 2010
Protein sequences encompass tertiary structures and contain information about specific molecular interactions, which in turn determine biological functions of proteins.
Angenent, G.C., Martijn Fiers, Roeland C H J van Ham, Roeland C. H. J. van Ham, Morabito Giuseppa, Ham, R.C.H.J., van, Aalt D J van Dijk, Angenent Gerco C., Immink, R.G.H., van Dijk, A.D.J., Richard G H Immink, van Dijk Aalt D. J., Morabito, G., van Ham Roeland C. H. J., Dijk, A.D.J., van, Fiers, M.A., Richard G. H. Immink, Giuseppa Morabito, van Ham, R.C.H.J., Aalt D. J. van Dijk, Immink Richard G. H., Gerco C Angenent, Gerco C. Angenent, Fiers Martijn   +23 more
core   +1 more source

The evolution of cyclodextrin glucanotransferase product specificity [PDF]

, 2009
Cyclodextrin glucanotransferases (CGTases) have attracted major interest from industry due to their unique capacity of forming large quantities of cyclic α-(1,4)-linked oligosaccharides (cyclodextrins) from starch.
Dijkhuizen, Lubbert; id_orcid, Leemhuis, Hans, Lubbert Dijkhuizen, Hans Leemhuis, Ronan M. Kelly, Dijkhuizen, Lubbert,, Dijkhuizen, Lubbert, Kelly, Ronan M.,, Leemhuis, Hans,, Kelly, Ronan M.   +9 more
core   +1 more source

The conformation of the nSrc specificity-determining loop in the Src SH3 domain is modulated by a WX conserved sequence motif found in SH3 domains

Frontiers in Molecular Biosciences
Cellular signaling networks are modulated by multiple protein-protein interaction domains that coordinate extracellular inputs and processes to regulate cellular processes. Several of these domains recognize short linear motifs, or SLiMs, which are often
Frederick Longshore-Neate, Caroline Ceravolo, Cole Masuga, Elise F. Tahti, Jadon M. Blount, Sarah N. Smith, Jeanine F. Amacher   +6 more
doaj   +1 more source

From Conceptual Specification to OO Specification

, 2023
Our earlier work showed how to improve the development path for an information system from initial user wishes via a conceptual specification (CS) to an implementation design in a systematic way. A CS should be implementation-independent. We generated implementations in a few directions, e.g., towards a relational DBMS using SQL. An object-oriented (OO)
Bert de Brock, Rein Smedinga
openaire   +2 more sources

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source