Results 71 to 80 of about 2,598,347 (318)
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Finding the Optimal Threshold of a Parametric ROC Curve Under a Continuous Diagnostic Measurement
Revstat Statistical Journal, 2018 The accuracy of a binary diagnostic test can easily be assessed by comparing the sensitivity and specificity with the status of respondents. When the result of a diagnostic test is continuous, the assessment of accuracy depends on a specified threshold.
Yi-Ting Hwang +3 more
doaj +1 more source
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
Ecotoxicology and Environmental SafetyAim: Long-term exposure to excess sodium fluoride (NaF) can cause chronic fluorosis. Liver, the most important detoxification organ, is the most vulnerable to the effects of fluoride.
Jing Xia +9 more
doaj
Accuracy Measures for Binary Classification Based on a Quantitative Variable
Revstat Statistical Journal, 2019 The identification of the right methodology to perform binary classification based on an observed quantitative variable is usually a complex choice. Thus, the use of appropriate accuracy measures is crucial.
Rui Santos +3 more
doaj +1 more source
, 2000 AbstractThis survey provides a route map, sketching the major issues, models, concepts, and techniques. A taxonomy of model types is presented, each being examined for advantages and drawbacks as a generic form. Exogeneity and the overall model reduction framework are described.
Hendry, D, Pagan, A, Sargan, J
openaire +4 more sources
FEBS Letters, EarlyView.The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp +5 more
wiley +1 more source
Brucella NyxA and NyxB dimerization enhances effector function during infection
FEBS Letters, EarlyView.Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre +4 more
wiley +1 more source
Improving hemodialysis patient depression outcomes with acupuncture: A randomized controlled trial
Acta PsychologicaObjective: To evaluate the efficacy and safety of acupuncture as a supplementary treatment for mild to moderate depression in hemodialysis patients. Method: This multicenter, randomized, controlled, single-masked trial included 64 hemodialysis patients ...
Xijing Yu +4 more
doaj
Toxins, 2012 Monoclonal antibodies (MAbs) have been employed either for diagnosis or treatment of infections caused by different pathogens. Specifically for Shiga toxin-producing Escherichia coli (STEC), numerous immunoassays have been developed for STEC diagnosis ...
Letícia B. Rocha +7 more
doaj +1 more source