Results 81 to 90 of about 4,456,677 (340)
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Topicality and (Non-)Specificity in Mandarin [PDF]
, 2001 Current analyses of specificity are unable to provide an explanatory account for why specific and nonspecific uses of indefinites are available. While Abusch (1994), Reinhart (1997), and Kratzer (1998) provide successful mechanisms for deriving specific ...
Portner, Paul
core
The selectivity and specificity of autophagy in drosophila [PDF]
, 2012 Autophagy is a process of cellular self-degradation and is a major pathway for elimination of cytoplasmic material by the lysosomes. Autophagy is responsible for the degradation of damaged organelles and protein aggregates and therefore plays a ...
Chou +27 more
core +2 more sources
A Specification Translation from Behavioral Specifications to Rewrite Specifications
IEICE Transactions on Information and Systems, 2008 There are two ways to describe a state machine as an algebraic specification: a behavioral specification and a rewrite specification. In this study, we propose a translation system from behavioral specifications to rewrite specifications to obtain a verification system which has the strong points of verification techniques for both specifications ...
Kokichi Futatsugi +3 more
openaire +3 more sources
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Domain Agnostic Real-Valued Specificity Prediction
, 2018 Sentence specificity quantifies the level of detail in a sentence, characterizing the organization of information in discourse. While this information is useful for many downstream applications, specificity prediction systems predict very coarse labels ...
Durrett, Greg +2 more
core +1 more source
Variation in Specificity of HIV Rapid Diagnostic Tests over Place and Time: An Analysis of Discordancy Data Using a Bayesian Approach [PDF]
, 2015 BACKGROUND Recent trends to earlier access to anti-retroviral treatment underline the importance of accurate HIV diagnosis. The WHO HIV testing strategy recommends the use of two or three rapid diagnostic tests (RDTs) combined in an algorithm and assume ...
Glass, Kathryn +5 more
core +1 more source
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
The evolutionary ecology of aphids' immunity
Invertebrate Survival Journal, 2011 Aphids comprise 4,400 species that live in close interactions with their host-plants, the parasitoid wasps and fungi they encounter, as well as several bacteria including Buchnera aphidicola, an obligatory, nutrient-providing symbiont.
M Poirié, C Coustau
doaj
Archives of Academic Emergency Medicine, 2023 Introduction: Several scoring systems have been proposed to predict the outcomes of patients with ischemic heart disease. Global Registry of Acute Coronary Events (GRACE) and History, ECG, Age, Risk Factors, and Troponin (HEART) scores are two of the ...
Ali Kabiri +5 more
doaj