Results 41 to 50 of about 3,158 (251)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Effect of stress path, size and shape on the optimum parameters of a brittle-ductile concrete model

Engineering Structures and Technologies, 2017
The main purpose of this study is to investigate the effects of the stress path, size and shape of the specimen, on the optimum values of the plastic input parameters of Concrete Damaged Plasticity-CDP- model of the ABAQUS software.
Mojtaba Labibzadeh, Reza Hamidi
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

On the use of simulated experiments in designing tests for material characterization from full-field measurements

, 2012
The present paper deals with the use of simulated experiments to improve the design of an actual mechanical test. The analysis focused on the identification of the orthotropic properties of composites using the unnotched Iosipescu test and a full-field ...
Fabrice Pierron, Rossi, Marco, Marco Rossi, F. Pierron, Pierron, Fabrice   +4 more
core   +1 more source

Design of a shear test fixture system and optimization of a metal shear specimen for cyclic loading

, 2023
The objective of the present paper is to investigate the optimization of the existing sheet metal specimen geometry and the optimization of fixtures for fatigue shear tests.
Nagode, Marko, Šeruga, Domen, Klemenc, Jernej, Litrop, Aljaž   +3 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Optimization of the Use Time of a Shake Table with Specimen Preparation outside the Table Surface

Buildings, 2022
The shake table test is one of the preferred techniques used to understand the dynamic response of a structure. However, due to the limited number of facilities available to perform such tests and their expensiveness, researchers often must rely on ...
Santosh Yadav, Yannick Sieffert, Florent Vieux-Champagne, Laurent Debove, Damien Decret, Yann Malecot, Philippe Garnier   +6 more
doaj   +1 more source

Optimization of notched tensile test specimen under plane strain condition

, 2022
In the current paper, specimen notch geometries during plane strain tensile test for cold-rolled steel DC01 is studied and optimized using Response Surface Methodology (RSM) and the desirability approach.
Lukács, Zsolt, Meknassi, Raid Fekhreddine, Lukács , Zsolt, Béres, Gábor József, Meknassi, Raid Fehreddine, Béres , Gábor   +5 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Innovative vibration technique applied to polyurethane foam as a viable substitute for conventional fatigue testing

Journal of the Mechanical Behavior of Materials, 2012
Lifetime prediction using three-point bending (TPB) can at times be prohibitively time consuming and costly, whereas vibration testing at higher frequency may potentially save time and revenue. A vibration technique that obtains lifetimes that reasonably
Peralta Alexander, Just-Agosto Frederick, Shafiq Basir, Serrano David   +3 more
doaj   +1 more source