Results 51 to 60 of about 103,020 (264)

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Comparison and optimization for DNA extraction of archived fish specimens

MethodsX, 2019
The DNA extracted from museum alcohol-fixed specimens can be a valuable source of information for solving taxonomic, phylogenetic, ecological and conservational questions. However, this type of DNA, also called ancient DNA, is routinely obtained in small portions and highly fragmented.
Priscilla C. Silva, Maria Claudia Malabarba, Richard Vari (In memoriam), Luiz R. Malabarba   +3 more
openaire   +3 more sources

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Design optimization of cruciform specimens for biaxial fatigue loading [PDF]

Fracture and Structural Integrity, 2014
In order to correctly assess the biaxial fatigue material properties one must experimentally test different load conditions and stress levels. With the rise of new in-plane biaxial fatigue testing machines, using smaller and more efficient electrical ...
R. Baptista , R. A. Claudio , L. Reis , I. Guelho , M. Freitas , J. F. A. Madeira   +5 more
doaj   +1 more source

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source

Enhancing preanalytic surgical specimen management: experience of a system implementation initiative

Diagnostic Pathology
Background /Objectives Preanalytic quality control of surgical specimens is often inadequately managed. This study aimed to share the experience of improving quality through the implementation of a system for preanalytic surgical specimens. Methods After
Peirong Chen, Weiming Qiu
doaj   +1 more source

GAD65 Antibody ELISA With Extended Reportable Range: Validation and Guidance for Neurological Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon, Dana Olofson, Diana Anissian, Divyanshu Dubey, Eoin P. Flanagan, Max C. Herman, Sarosh R. Irani, Daniel H. Lachance, Maria A. Willrich, Sean Pittock, John R. Mills, Anastasia Zekeridou   +11 more
wiley   +1 more source

Data-Driven Performance-Oriented Rapid Process Optimization for 316 Stainless Steels Prepared by Laser Powder Bed Fusion

Metals
In this work, a rapid process optimization framework for laser powder bed fusion (LPBF) based on a high-throughput mechanical testing platform and data analytical methods was proposed and validated.
Junyan Zhu, Meiling Jiang, Guoliang Huang, Ke Huang   +3 more
doaj   +1 more source

Fatigue strength characterization of Al-Si cast material incorporating statistical size effect

MATEC Web of Conferences, 2018
Cast aluminium components may exhibit material imperfections such as shrinkage and gas pores, or oxide inclusions. Therefore, the fatigue resistance is significantly influenced by the size and location of these inhomogenities. In this work, two different
Aigner Roman, Leitner Martin, Stoschka Michael   +2 more
doaj   +1 more source

TOPOLOGICAL OPTIMIZATION OF THE TEST SPECIMEN FOR BIAXIAL TENSION

Problems of Strength and Plasticity, 2019
Applying the approaches of topology optimization, we consider the problem of substantiation of the configuration of the 2D test specimen, in the workspace of which the biaxial stress-strain state is realized. The original area occupied by the specimen is a square plate with a given side size made of an isotropic material.
A. V. Zhidkov, V. G. Kiselev, A. K. Lyubimov, O. A. Sergeev, A. V. Basalin   +4 more
openaire   +2 more sources