Results 71 to 80 of about 2,836,187 (243)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Bactericides Based on Copper Nanoparticles Restrain Growth of Important Plant Pathogens

Pathogens, 2020
Copper nanoparticles (CuNPs) can offer an alternative to conventional copper bactericides and possibly slow down the development of bacterial resistance.
Adamantia Varympopi, Anastasia Dimopoulou, Ioannis Theologidis, Theodora Karamanidou, Alexandra Kaldeli Kerou, Afroditi Vlachou, Dimitrios Karfaridis, Dimitris Papafotis, Dimitris G. Hatzinikolaou, Alexander Tsouknidas, Nicholas Skandalis   +10 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Breaking the speed limitation of wavemeter through spectra-space-time mapping

Light: Advanced Manufacturing
Speckle patterns generated by the intermodal interference of multimode fibers enable accurate broadband wavelength measurements. However, the measurement speed is limited by the frame rate of the camera that captures the patterns.
Zheng Gao, Ting Jiang, Mingming Zhang, Yuxuan Xiong, Hao Wu, Ming Tang   +5 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Power spectra of velocities and magnetic fields on the solar surface and their dependence on the unsigned magnetic flux density

, 2012
We have performed power spectral analysis of surface temperatures, velocities, and magnetic fields, using spectro-polarimetric data taken with the Hinode Solar Optical Telescope.
Abramenko, Abramenko, Abramenko, D. Orozco Suárez, Durrant, Espagnet, Goode, Ishikawa, Ishikawa, Lites, Lites, Orozco Suárez, Orozco Suárez, Pietarila Graham, Pietarila Graham, Rieutord, Roudier, Y. Katsukawa, Yelles Chaouche   +18 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Symmetric spectra

, 1998
The long hunt for a symmetric monoidal category of spectra finally ended in success with the simultaneous discovery of the third author's discovery of symmetric spectra and the Elmendorf-Kriz-Mandell-May category of S-modules. In this paper we define and
Hovey, Mark, Shipley, Brooke, Smith, Jeff   +2 more
core   +3 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source