Results 141 to 150 of about 235,731 (299)

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

Dynamic effective stress analysis of a site with liquefiable interlayer: considering vertical and horizontal ground motion

Frontiers in Earth Science
This study uses a fully coupled dynamic effective stress analysis method to evaluate the seismic response of a site containing silty sand which is a liquefiable interlayer.
Xiao-Bo Peng, Yuan Gao, Ying-Ying Xue, Xiao-San Tao, Ling-Yu Xu   +4 more
doaj   +1 more source

Some Experiences of Improving the Speed of Numerical Navier-Stokes Solver Using CUDA

Journal of Algorithms & Computational Technology, 2014
In this paper, the Graphics Processor Unit (GPU) is adopted to accelerate the codes of solving incompressible Navier-Stokes equations with two fully different numerical schemes: spectral method and finite difference method. Compared with the codes on CPU,
Kaiyuan Lou, Qiaohong Li, Zhaohua Yin
doaj   +1 more source

Advancing Age Modulates Associations Between Cognitive Impairment and Brain Volumes in Early MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Cognitive impairment is common in multiple sclerosis (MS), but manifestations following the first demyelinating event are relatively unexplored. We investigated cross‐sectional associations between magnetic resonance imaging (MRI)–derived brain volumes and the presence of cognitive impairment outcomes five years after the first ...
Piriyankan Ananthavarathan, Marco Pitteri, Michael Foster, Sara Collorone, Sara Salama, Elisa Colato, Ferran Prados, Baris Kanber, Marios Yiannakas, Claudia A. M. Gandini Wheeler‐Kingshott, Indran Davagnanam, Frederik Barkhof, Declan Chard, Olga Ciccarelli, Ahmed Toosy   +14 more
wiley   +1 more source

A comparative study of two models for the seismic analysis of buildings

Ingeniería e Investigación, 2012
This paper presents a model for the seismic analysis of buildings, taking two lumped masses at each level in a structure’s free nodes and comparing them to the traditional model which considers lumped masses per level, i.e., a mass for each floor of the ...
Arnulfo Luévanos Rojas
doaj  

Movement Disorders in Aicardi–Goutières Syndrome and Response to Immunomodulation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This study characterizes movement disorders and treatment responses in seven children with Aicardi–Goutières syndrome (AGS). We retrospectively evaluated motor phenotypes, neuroimaging, and interferon signatures in patients treated with baricitinib or anifrolumab. Spasticity affected all patients, while dystonia was present in 4/7.
Enrique Gonzalez Saez‐Diez, Monica Ferrer Socorro, Kathryn Yang, Nicole Battaglia, Zainab Zaman, Mariko Bennett, Adeline Vanderver, Pui Y. Lee, Lauren A. Henderson, Milena M. Andzelm, Darius Ebrahimi‐Fakhari   +10 more
wiley   +1 more source

General spectral characteristics of human activity and its inherent scale-free fluctuations

Scientific Reports
The scale-free nature of daily human activity has been observed in different aspects; however, the description of its spectral characteristics is incomplete.
Bálint Maczák, Zoltán Gingl, Gergely Vadai   +2 more
doaj   +1 more source

MOGAD Is the Most Common Cause of Isolated Optic Neuritis in Children

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives The study aimed to characterize the clinical features, etiologies, and outcomes of isolated, first‐time pediatric ON in the post‐MOG‐IgG era. Methods This was a single‐center retrospective cohort study at Texas Children's Hospital of patients diagnosed with first‐time ON between 2018–2024, with follow‐up data collected through 2025.
Chaitanya Aduru, Akansha Chandrasekar, Kyla Blasingame, Jonathan Rosen, Jesse M. Levine, Karla Salazar, Madhuri Chilakapati, Rod Foroozan, Victoria Hardwick, Jonathan M. Yarimi, Nikita Shukla, Timothy E. Lotze, Kristen S. Fisher, Alexander J. Sandweiss   +13 more
wiley   +1 more source

Observational Evidence of Particle Acceleration by Relativistic Magnetic Reconnection in Gamma-Ray Bursts

The Astrophysical Journal
Gamma-ray bursts (GRBs) as the most energetic explosions in the modern universe have been studied for over half a century, but the physics of the particle acceleration and radiation responsible for their observed spectral behaviors are still not well ...
Cheng-Feng Peng, Rui-Jing Lu, Wen-Qiang Liang, Zhe-geng Chen   +3 more
doaj   +1 more source

Clinical Impact of NOTCH3 Variant Location After First Stroke in CADASIL

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Despite its monogenic origin, Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy exhibits marked variability in clinical expression and severity. Variants in the NOTCH3 gene, within epidermal growth factor‐like repeat domains 1–6 or 7–34, are known to influence disease onset, but their impact ...
Léa Aguilhon, Hugues Chabriat, Dominique Hervé, Stéphanie Guey, Sophie Tezenas Du Montcel, Juliette Ortholand   +5 more
wiley   +1 more source