Results 41 to 50 of about 1,208,920 (250)

Probabilistic seismic hazard analysis using a new ground motion intensity measure

Dyna, 2016
The main objective of this work is to compute the probabilistic seismic hazard analysis for a region of Mexico using a new ground motion intensity measure which is based on the spectral acceleration and a parameter proxy of the spectral shape named Np ...
Robespiere Chávez López, Edén Bojórquez-Mora   +1 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Exploring the Origin of Solar Energetic Electrons. II. Investigating Turbulent Coronal Acceleration

The Astrophysical Journal
Nonthermal particle acceleration in the solar corona is evident from both remote hard X-ray sources in the chromosphere and direct in situ detection in the heliosphere.
Ross Pallister, Natasha L. S. Jeffrey, Morgan Stores   +2 more
doaj   +1 more source

Metodología de modelación de escenarios de riesgo sísmico en Managua, Nicaragua

Nexo, 2010
The research methodology for seismic risk scenarios modeling in Managua, Nicaragua was carried out by the CENTRAL AMERICA SEISMIC RISK REDUCTION PROJECT (RESIS II) in phase II under the auspices of the center for disaster prevention in Central America ...
A. Ugarte
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Seismic Acceleration Spectrum of Ground Surface under Urban Subway Tunnels with Circular Cross Sections in Soil Deposits Based on SSI

Shock and Vibration, 2019
Underground tunnels with circular cross section nowadays have great application in the field of transportation. One of their most prominent uses is the subway, built with the help of tunnel boring machines (TBMs).
Hamed Fakhriyeh, Reza Vahdani, Mohsen Gerami   +2 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Unveiling Differences in Seismic Response: Comparative Study of Equivalent Linear and Nonlinear Analyses in the Central Coastal Region of Bengkulu, Indonesia

Journal of the Civil Engineering Forum
Seismic response analysis is a key aspect in earthquake geotechnical engineering, as it provides important insights into the behavior of soils when exposedtoseismic forces.
Giovanny Dhebby Anggraini, Lindung Zalbuin Mase, Fepy Supriani, Rena Misliniyati, Khairul Amri, Salisa Chaiyaput   +5 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source