Results 51 to 60 of about 528,301 (219)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Additional Minor Diterpene Glycosides from Stevia rebaudiana Bertoni

Molecules, 2013
Two additional novel minor diterpene glycosides were isolated from the commercial extract of the leaves of Stevia rebaudiana Bertoni. The structures of the new compounds were identified as 13-{β-D-glucopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→3)-β-D ...
Indra Prakash, Venkata Sai Prakash Chaturvedula   +1 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

System of Kaup Equations with a Loaded Term in the Class of Periodic Functions

Известия Иркутского государственного университета: Серия "Математика"
In this paper, a system of nonlinear Kaup equations with a loaded additional term in the class of periodic functions with respect to the spatial variable is considered.
A.B. Yakhshimuratov, O. M. Matyokubov
doaj   +1 more source

Estimation of standing wood volume and species composition in managed nemoral multi-layer mixed forests by using nearest neighbour classifier, multispectral satellite images and airborne lidar data / Puistute liigilise koosseisu ja tüvemahu hindamine k-lähima naabri meetodil mitmerindelistes majandatavates segametsades

Metsanduslikud Uurimused, 2014
Nearest neighbour techniques are useful for constructing maps of forest inventory variables based on sample plot and auxiliary data from remote sensing.
Lang Mait, Arumäe Tauri, Lükk Tõnu, Sims Allan   +3 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Novel Mannich Base Complexes of 5-Chloro-1,3-benzoxazole-2(3H)-thione as Antioxidant and Anticancer Agents

Journal of the Turkish Chemical Society, Section A: Chemistry
A new ligand of Mannich base (5-chloro-3-(dibenzyl amino) (phenyl)methyl) benzo[d]oxazole-2(3H)-thione) (L1) was synthesized. Micro complexes (CuL1) and (ZnL1) were synthesized, and their anti-tumor and antioxidant activity against cancer cells (MCF-7 ...
Marwa Jassim Al-Muhamadawi, Rehab Abdul Mahdi Al-Hassani   +1 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source