Results 41 to 50 of about 539,151 (294)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Numerical Solution for Elliptic Interface Problems Using Spectral Element Collocation Method

Abstract and Applied Analysis, 2014
The aim of this paper is to solve an elliptic interface problem with a discontinuous coefficient and a singular source term by the spectral collocation method.
Peyman Hessari, Sang Dong Kim, Byeong-Chun Shin   +2 more
doaj   +1 more source

Exact calculation of Fourier series in nonconforming spectral-element methods

, 2005
In this note is presented a method, given nodal values on multidimensional nonconforming spectral elements, for calculating global Fourier-series coefficients.
Aimé Fournier, Arfken, Basdevant, Boyd, Deville, Fournier   +5 more
core   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Spectral Stochastic Finite Element Method for Electromagnetic Problems with Random Geometry

Electrical, Control and Communication Engineering, 2014
In electromagnetic problems, the problem geometry may not always be exactly known. One example of such a case is a rotating machine with random-wound windings.
Lehikoinen Antti
doaj   +1 more source

Numerical methods of geodynamics in big data era: Review and outlook

地球与行星物理论评, 2021
With the advent of the era of big data, the framework of numerical method of computational geodynamics is perfected. In this paper, we review systematically the conventional numerical simulation methods in the field of computational geodynamics, included
Bei Zhang, Gabriele Morra, David A. Yuen, Henry R. Tufo, Matthew G. Knepley, Shi Chen   +5 more
doaj   +1 more source

Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle, Kiersten Ricci, Kelly Blache, Rebecca A. Marsh, Adrienne M. Hammill, Elissa Engel   +5 more
wiley   +1 more source

Quasi-3-D spectral wavelet method for a thermal quench simulation

Journal of Mathematics in Industry, 2021
The finite element method is widely used in simulations of various fields. However, when considering domains whose extent differs strongly in different spatial directions a finite element simulation becomes computationally very expensive due to the large
Jonas Bundschuh, Laura A. M. D’Angelo, Herbert De Gersem   +2 more
doaj   +1 more source

A comparison of spectral element and finite difference methods using statically refined nonconforming grids for the MHD island coalescence instability problem

, 2007
A recently developed spectral-element adaptive refinement incompressible magnetohydrodynamic (MHD) code [Rosenberg, Fournier, Fischer, Pouquet, J. Comp. Phys.
A. Bhattacharjee, A. Pouquet, Basdevant C., C. S. Ng, D. Rosenberg, Dennis J. M., Fischer P. F., Fischer P. F., K. Germaschewski, Kellogg E., Li X. S., Longcope D. W., Mavriplis C., Ng C. S., Rosenberg D., Rosenberg D., St-Cyr A.   +16 more
core   +1 more source

The Fate (Outcome) of Clinically Apparent Single Lesion and Oligofocal Nephroblastomatosis Treated According to SIOP/GPOH Protocols for Wilms Tumor

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background The management of clinically apparent single lesions or oligofocal nephroblastomatosis, a facultative precursor of nephroblastoma, remains debated. Methods We retrospectively analyzed 37 patients with clinically apparent single or oligofocal nephroblastomatosis (two to three lesions per kidney) among 2347 patients registered between
Nils Welter, Jens‐Peter Schenk, Jenny Wegert, Manfred Gessler, Leo Kager, Stefan Wagenpfeil, Marina Müller, Jean‐Michel Wolff, Joerg Fuchs, Steven W. Warmann, Clemens‐Magnus Meier, Jochen Hubertus, Christian Rübe, Christian Vokuhl, Patrick Melchior, Lena Tschirner, Norbert Graf, Rhoikos Furtwängler   +17 more
wiley   +1 more source