Results 121 to 130 of about 322,666 (307)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Integration of Unmanned Aerial Vehicle Spectral and Textural Features for Accurate Above-Ground Biomass Estimation in Cotton

Agronomy
Timely and accurate estimation of Above-Ground-Biomass (AGB) in cotton is essential for precise production monitoring. The study was conducted in Shaya County, Aksu Region, Xinjiang, China.
Maoguang Chen, Caixia Yin, Tao Lin, Haijun Liu, Zhenyang Wang, Pingan Jiang, Saif Ali, Qiuxiang Tang, Xiuliang Jin   +8 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Monitoring Plastic-Mulched Farmland by Landsat-8 OLI Imagery Using Spectral and Textural Features

Remote Sensing, 2016
In recent decades, plastic-mulched farmland has expanded rapidly in China as well as in the rest of the world because it results in marked increases of crop production. However, plastic-mulched farmland significantly influences the environment and has so
Hasituya, Zhongxin Chen, Limin Wang, Wenbin Wu, Zhiwei Jiang, He Li   +5 more
doaj   +1 more source

Spectral Self-supervised Feature Selection

CoRR
TMLR ...
Daniel Segal, Ofir Lindenbaum, Ariel Jaffe   +2 more
openaire   +3 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Spectral and Entropic Features Are Altered by Age in the Electroencephalogram in Patients under Sevoflurane Anesthesia.

, 2020
BACKGROUND Preexisting factors such as age and cognitive performance can influence the electroencephalogram (EEG) during general anesthesia. Specifically, spectral EEG power is lower in elderly, compared to younger, subjects.
Sleigh, James W, García, Paul S, Kreuzer, Matthias, Berger, Sebastian, Schneider, Gerhard, Stern, Matthew A, Hight, Darren   +6 more
core   +1 more source

A flexible spectral modification method based on temporal decomposition and Gaussian mixture model [PDF]

, 2009
Manipulating spectral structure often leads to degradation of speech quality, which is mainly due to insufficient smoothness of the modified spectra between frames, and ineffective spectralmodification.
Masato Akagi, Akagi, Masato, Binh Phu Nguyen, Nguyen, Binh Phu   +3 more
core   +1 more source

Enhancing Insect Sound Classification Using Dual-Tower Network: A Fusion of Temporal and Spectral Feature Perception

Applied Sciences
In the modern field of biological pest control, especially in the realm of insect population monitoring, deep learning methods have made further advancements.
Hangfei He, Junyang Chen, Hongkun Chen, Borui Zeng, Yutong Huang, Yudan Zhaopeng, Xiaoyan Chen   +6 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source