Results 111 to 120 of about 5,686,377 (385)

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Synthesis of the Beryllium 3131A Spectral Region [PDF]

, 2005
The Beryllium spectral region of the Sun, Procyon and 4 stars in the open cluster NGC6633 up to Teff = 7500K have been synthesised using ATLAS9 model atmospheres and the MOOG spectral synthesis program.
Ashwell, Johanna F., Jeffries, R. D., Smalley, B.   +2 more
core   +2 more sources

Spectral Structure of Quantum Line with a Defect

, 2001
We study the spectral properties of one-dimensional quantum wire with a single defect. We reveal the existence of the non-trivial topological structures in the spectral space of the system, which are behind the exotic quantum phenomena that have lately ...
Cheon, Taksu, Fulop, Tamas, Tsutsui, Izumi   +2 more
core   +2 more sources

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

On broad iron K-alpha lines in Seyfert 1 galaxies

, 1995
The X-ray spectrum obtained by Tanaka et al from a long observation of the active galaxy MCG$-6-30-15$ shows a broad iron K$\alpha$ line skewed to low energies.
Brandt, W. N., Fabian, A. C., Inoue, H., Iwasawa, K., Nandra, K., Otani, C., Reynolds, C. S., Tanaka, Y.   +7 more
core   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

Molecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi   +11 more
wiley   +1 more source

A new index for detection of submerged aquatic plants under variable quality water: an extension of the soil-line concept

GIScience & Remote Sensing
Submersed aquatic plant (SAP) communities are important determinants of estuarine and lacustrine food web structure, nutrient cycling, and water quality.
Shruti Khanna, Erin L. Hestir, Joaquim Bellvert, Jennifer D. Boyer, Kristen D. Shapiro, Susan L. Ustin   +5 more
doaj   +1 more source

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

Molecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton, Russell W. Madison, Candice Francheska B. Tambaoan, Funda Meric‐Bernstam, Christopher J. Sweeney, Razelle Kurzrock, Howard A. Burris III, David R. Spigel, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W. Pasquina, Amaya Gasco, Katja Schulze, Claire F. Friedman   +17 more
wiley   +1 more source

Bayesian Model Reconstruction Based on Spectral Line Observations

The Astrophysical Journal Supplement Series
Spectral line observations encode a wealth of information. A key challenge, therefore, lies in the interpretation of these observations in terms of models to derive the physical and chemical properties of the astronomical environments from which they ...
Frederik De Ceuster, Thomas Ceulemans, Leen Decin, Taïssa Danilovich, Jeremy Yates   +4 more
doaj   +1 more source

Doppler Broadening of Spectral Line Shapes in Relativistic Plasmas

Atoms, 2018
In this work, we report some relativistic effects on the spectral line broadening. In particular, we give a new Doppler broadening in extra hot plasmas that takes into account the possible high velocity of the emitters.
Mohammed Tayeb Meftah, Hadda Gossa, Kamel Ahmed Touati, Keltoum Chenini, Amel Naam   +4 more
doaj   +1 more source