Results 41 to 50 of about 1,274,676 (322)

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

On the complete integrability of the discrete Nahm equations

, 1999
The discrete Nahm equations, a system of matrix valued difference equations, arose in the work of Braam and Austin on half-integral mass hyperbolic monopoles. We show that the discrete Nahm equations are completely integrable in a natural sense: to any
Murray, Michael K., Singer, Michael A.
core   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Systematic Uncertainties in Black Hole Masses Determined from Single Epoch Spectra [PDF]

, 2008
We explore the nature of systematic errors that can arise in measurement of black hole masses from single-epoch spectra of active galactic nuclei (AGNs) by utilizing the many epochs available for NGC 5548 and PG1229+204 from reverberation mapping ...
Bentz, Bentz, Bentz, Bradley M. Peterson, Busko, Cappellari, Dietrich, Dietrich, Elvis, Ferrarese, Ferrarese, Fine, Gebhardt, Gebhardt, Kaspi, Kaspi, Kelly, Kelly D. Denney, Kollmeier, Korista, Kormendy, Marianne Vestergaard, Matthias Dietrich, McGill, Misty C. Bentz, Nelson, Netzer, Onken, Onken, Peterson, Peterson, Peterson, Peterson, Peterson, Schlegel, Shen, Shen, Tremaine, Vestergaard, Vestergaard, Vestergaard, Vestergaard, Vestergaard, Wilhite, Woo   +44 more
core   +3 more sources

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Special Issue on Spectral Line Shapes in Plasmas

Atoms, 2014
Line-shape analysis is one of the most important tools for diagnostics of both laboratory and space plasmas. Its reliable implementation requires sufficiently accurate calculations, which imply the use of analytic methods and computer codes of varying ...
Evgeny Stambulchik, Annette Calisti, Hyun-Kyung Chung, Manuel Á. González   +3 more
doaj   +1 more source

The molecular emission-line spectrum of IRC +10216 between 330 and 358 GHz [PDF]

, 1994
We have conducted a spectral line survey of IRC + 10216 using the Caltech Submillimeter Observatory to an average sensitivity of ≾95 mK. A deconvolution algorithm has been used to derive the continuous single-sideband spectrum from 330.2 to 358.1 GHz ...
Blake, Geoffrey A., Groesbeck, T. D., Phillips, T. G.   +2 more
core   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Iterative solution of a discrete axially symmetric potential problem [PDF]

, 1975
The Dirichlet problem for the axially symmetric potential equation in a cylindrical domain is discretized by means of a five-point difference approximation. The resulting difference equation is solved by point or line iterative methods.
Boersma, J., Le Grand, P.
core   +2 more sources

The intracellular domain of TLR2 is capable of high‐affinity Zn binding: possible outcomes for the receptor activation

FEBS Letters, EarlyView.
Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa, Cong Lin, Irina A. Talyzina, Marina V. Goncharuk, Eduard V. Bocharov, Alexander S. Arseniev, Xiaohui Wang, Sergey A. Goncharuk, Konstantin S. Mineev   +8 more
wiley   +1 more source