Results 81 to 90 of about 114,083 (289)

On the Abiotic Origin of Dimethyl Sulfide: Discovery of Dimethyl Sulfide in the Interstellar Medium

The Astrophysical Journal Letters
Following the discovery of dimethyl sulfide (DMS; CH _3 SCH _3 ) signatures in comet 67P/Churyumov–Gerasimenko, we report the first detection of this organosulfur species in the interstellar medium during the exploration of an ultradeep molecular line ...
Miguel Sanz-Novo, Víctor M. Rivilla, Christian P. Endres, Valerio Lattanzi, Izaskun Jiménez-Serra, Laura Colzi, Shaoshan Zeng, Andrés Megías, Álvaro López-Gallifa, Antonio Martínez-Henares, David San Andrés, Belén Tercero, Pablo de Vicente, Sergio Martín, Miguel A. Requena-Torres, Paola Caselli, Jesús Martín-Pintado   +16 more
doaj   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Discovery of Thionylimide, HNSO, in Space: The first N-, S-, and O-bearing Interstellar Molecule

The Astrophysical Journal Letters
We present the first detection in space of thionylimide (HNSO) toward the Galactic center molecular cloud G + 0.693-0.027, thanks to the superb sensitivity of an ultradeep molecular line survey carried out with the Yebes 40 m and IRAM 30 m telescopes ...
Miguel Sanz-Novo, Víctor M. Rivilla, Holger S. P. Müller, Izaskun Jiménez-Serra, Jesús Martín-Pintado, Laura Colzi, Shaoshan Zeng, Andrés Megías, Álvaro López-Gallifa, Antonio Martínez-Henares, Belén Tercero, Pablo de Vicente, David San Andrés, Sergio Martín, Miguel A. Requena-Torres   +14 more
doaj   +1 more source

Statistical Methods in the Identification and Prediction of the Solar X-Ray Spectral Lines [PDF]

Symposium - International Astronomical Union, 1975
SummaryWith the accumulation of numerous identifications of the solar X and XUV spectral lines, the need is felt for systemizing such identification. The results are presented below.
openaire   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Discovery of MgS and NaS in the Interstellar Medium and Tentative Detection of CaO

The Astrophysical Journal
We report the first detection of the metal-bearing molecules sodium sulfide and magnesium sulfide and the tentative detection of calcium monoxide in the interstellar medium toward the Galactic center molecular cloud G+0.693-0.027.
Marta Rey-Montejo, Izaskun Jiménez-Serra, Jesús Martín-Pintado, Víctor M. Rivilla, Andrés Megías, David San Andrés, Miguel Sanz-Novo, Laura Colzi, Shaoshan Zeng, Álvaro López-Gallifa, Antonio Martínez-Henares, Sergio Martín, Belén Tercero, Pablo de Vicente, Miguel Requena-Torres   +14 more
doaj   +1 more source

Rail Transit Radiation Source Identification Method Based on Enhanced Diagonal Integral Bispectrum

Chengshi guidao jiaotong yanjiu
[Objective] Numerous external interference signals exist in urban rail transit wireless communication system, posing a significant threat to operational safety.
Haichuan LIU, Kexin ZHANG, Hui HUI, Lu WEN   +3 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Separation and Identification of Highly Fluorescent Compounds Derived from trans-Resveratrol in the Leaves of Vitis vinifera Infected by Plasmopara viticola

Molecules, 2012
A method for identification of highly fluorescent compounds in vine leaves infected by Plasmopara viticola was developed using reversed phase liquid chromatography with simultaneous diode array and fluorometric detection.
Radek Sotolář, Rudolf Jílek, Julie Olejníčková, Jan Tříska, Naděžda Vrchotová   +4 more
doaj   +1 more source