Results 61 to 70 of about 119,847 (263)
Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach
FEBS Letters, EarlyView.The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
The Astrophysical JournalIn kilonovae, freshly synthesized r -process elements imprint features on optical spectra, as observed in AT2017gfo, the counterpart to the GW170817 binary neutron star merger.
Nicholas Vieira +5 more
doaj +1 more source
Sensors, 2009 Plasma optical spectroscopy is widely employed in on-line welding diagnostics. The determination of the plasma electron temperature, which is typically selected as the output monitoring parameter, implies the identification of the atomic emission lines ...
Olga M. Conde +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Interstellar Detection of O-protonated Carbonyl Sulfide, HOCS+
The Astrophysical JournalWe present the first detection in space of O-protonated carbonyl sulfide (HOCS ^+ ), in the midst of an ultradeep molecular line survey toward the G+0.693-0.027 molecular cloud. From the observation of all K _a = 0 transitions ranging from J _lo = 2 to J
Miguel Sanz-Novo +14 more
doaj +1 more source
Identification of single spectral lines through machine learning
, 2019 The Identification of redshifted spectral lines is unequivocal when multiple lines with high S/N ratios are detected. In these cases, the distances measured between each pair of lines represent the reference used for the identification. However, when only one spectral line is detected, its identification becomes extremely difficult.
openaire +2 more sources
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Computational and Structural Biotechnology JournalRaman spectroscopy extracts rich biochemical information on a single cell, demonstrating significant potential for precise cancer identification. While machine learning enhances spectral analysis efficiency, conventional models remain constrained by data
Yiheng Liu +5 more
doaj +1 more source