Results 51 to 60 of about 118,845 (247)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, Volume 20, Issue 6, Page 1398-1419, June 2026.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

On-line parameter and delay estimation of continuous-time dynamic systems

International Journal of Applied Mathematics and Computer Science, 2015
The problem of on-line identification of non-stationary delay systems is considered. The dynamics of supervised industrial processes are usually modeled by ordinary differential equations.
Kozłowski Janusz, Kowalczuk Zdzisław
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, Volume 20, Issue 6, Page 1453-1472, June 2026.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Molecular Hydrogen Line Identifications in Solar Flares Observed by IRIS: Lower Atmospheric Structure from Radiometric Analysis

The Astrophysical Journal
A rich spectrum of molecular hydrogen (H _2 ) emission lines is seen in sensitive observations from the far-ultraviolet (FUV) channels of the Interface Region Imaging Spectrograph (IRIS) during flare activity in solar active region NOAA Active Region ...
Sarah A. Jaeggli, Adrian N. Daw
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Maser Activity of Organic Molecules toward Sgr B2(N)

The Astrophysical Journal
At centimeter wavelengths, single-dish observations have suggested that the Sagittarius (Sgr) B2 molecular cloud at the Galactic Center hosts weak maser emission from several organic molecules, including CH _2 NH, HNCNH, and HCOOCH _3 . However, the lack
Ci Xue, Anthony Remijan, Alexandre Faure, Emmanuel Momjian, Todd R. Hunter, Ryan A. Loomis, Eric Herbst, Brett McGuire   +7 more
doaj   +1 more source

Statistical Methods in the Identification and Prediction of the Solar X-Ray Spectral Lines [PDF]

Symposium - International Astronomical Union, 1975
SummaryWith the accumulation of numerous identifications of the solar X and XUV spectral lines, the need is felt for systemizing such identification. The results are presented below.
openaire   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, Volume 20, Issue 6, Page 1473-1493, June 2026.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Revisiting Near-infrared Features of Kilonovae: The Importance of Gadolinium

The Astrophysical Journal
The observation of the kilonova AT2017gfo and investigations of its light curves and spectra confirmed that neutron star mergers are sites of r -process nucleosynthesis.
Salma Rahmouni, Masaomi Tanaka, Nanae Domoto, Daiji Kato, Kenta Hotokezaka, Wako Aoki, Teruyuki Hirano, Takayuki Kotani, Masayuki Kuzuhara, Motohide Tamura   +9 more
doaj   +1 more source

Defect Detection in Arc-Welding Processes by Means of the Line-to-Continuum Method and Feature Selection

Sensors, 2009
Plasma optical spectroscopy is widely employed in on-line welding diagnostics. The determination of the plasma electron temperature, which is typically selected as the output monitoring parameter, implies the identification of the atomic emission lines ...
Olga M. Conde, Adolfo Cobo, P. Beatriz Garcia-Allende, Jesus Mirapeix, Jose M. Lopez-Higuera   +4 more
doaj   +1 more source