Results 41 to 50 of about 118,845 (247)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The Optical System Design of a Space-Based Wide-Field Infrared Slitless Spectrometer

Photonics
With the increasingly complex space environment, the operational safety of spacecraft faces severe challenges, creating an urgent need to develop efficient and reliable space target detection and identification technologies. Traditional optical detection
Yue Chen, Liang Zhou, Peiquan Chen, Pengkai Dong, Haiyang Zhang, Wenji She   +5 more
doaj   +1 more source

Identification of Vehicle System Dynamics from the Aspect of Interaction between the Steering and the Suspension Systems

Machines, 2022
Steering and suspension systems of a motor vehicle have very important mutual connections that have direct influence on a vehicle’s steerability, stability, comfort and life expectancy.
Danijela Miloradović, Jovanka Lukić, Jasna Glišović, Nenad Miloradović   +3 more
doaj   +1 more source

Identification of phase-independent spectral lines in close binary V455 CYG: I. Telluric lines

Serbian Astronomical Journal, 2007
Spectroscopic observations of close binary star V455 Cygni reveal many lines that originate in interstellar and circumstellar medium and the atmo?sphere of the Earth; we found over two hundred such spectral features, and in this paper we present the list of telluric lines we identified through comparison with HITRAN database of molecular lines.
Cséki A., Vince I., Latković O., Antokhin I.I.   +3 more
openaire   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

HelioSpectrotron 5000: an interactive solar atlas

The Open Journal of Astrophysics
HelioSpectrotron 5000 (HS5000) is an interactive, multi-resolution solar spectral atlas designed to facilitate direct comparison between high-resolution reference spectra and observations obtained with a wide range of ground-based instruments.
Alexander G.M. Pietrow
doaj   +1 more source

Application of the Goertzel’s algorithm in the airgap mixed eccentricity fault detection [PDF]

Serbian Journal of Electrical Engineering, 2015
In this paper, a suitable method for the on-line detection of the airgap mixed eccentricity fault in a three-phase cage induction motor has been proposed.
Reljić Dejan, Tomić Josif, Kanović Željko   +2 more
doaj   +1 more source