Results 91 to 100 of about 999,597 (267)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
A 10-hour period revealed in optical spectra of the highly variable WN8 Wolf-Rayet star WR 123
, 2011 Aims. What is the origin of the large-amplitude variability in Wolf-Rayet WN8 stars in general and WR123 in particular? A dedicated spectroscopic campaign targets the ten-hour period previously found in the high-precision photometric data obtained by the
A. F. J. Moffat +33 more
core +2 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Charge of ions emitting spectral lines [PDF]
Ion charge determination from emitting spectral lines using beam foil light source ...
Bashkin, S., Carriveau, G. W.
core +1 more source
, 2005 Until now, the spectral changes observed from persistent to dipping intervals in dipping low-mass X-ray binaries were explained by invoking progressive and partial covering of an extended emission region.
A.N. Parmar +6 more
core +2 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
ESTIMATIONS OF LOCAL MAGNETIC FIELDS IN SOLAR FLARES: BASIC METHODS AND SOME RESULTS
Odessa Astronomical Publications, 2017 We consider three methods for estimations of local magnetic fields in solar flares: (1) analysis of bisectors of I ± V profiles (Lozitsky, 2015); (2) search for Zeeman-like effects in cores of spectral lines with very low Lande factors, geff ≈ 0.01 ...
V. G. Lozitsky +3 more
doaj +1 more source
Citation: 'spectral line' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.08550 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms. Requests for
openaire +1 more source
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source