Results 81 to 90 of about 999,597 (267)

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Simulation of a flux emergence event and comparison with observations by Hinode

, 2009
We study the observational signature of flux emergence in the photosphere using synthetic data from a 3D MHD simulation of the emergence of a twisted flux tube. Several stages in the emergence process are considered.
A. Lagg, Abbett, Archontis, Borrero, Brants, Brants, Centeno, Cheung, Cheung, Danilovic, Frutiger, Hagenaar, Ishikawa, Isobe, Khomenko, Khomenko, Kubo, L. Yelles Chaouche, Lagg, Lagg, Lites, Lites, Lites, M. C. M. Cheung, M. Schüssler, Magara, Martínez González, Martínez-Sykora, Okamoto, Okamoto, S. K. Solanki, Shchukina, Shelyag, Shibata, Sigwarth, Solanki, Strous, Strous, Tsuneta, Vögler, Vögler, Wiegelmann, Zwaan, Zwaan   +43 more
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Bayesian Multi-line Intensity Mapping

The Astrophysical Journal
Line intensity mapping (LIM) has emerged as a promising tool for probing the 3D large-scale structure through the aggregate emission of spectral lines.
Yun-Ting Cheng, Kailai Wang, Benjamin D. Wandelt, Tzu-Ching Chang, Olivier Doré   +4 more
doaj   +1 more source

Optical spectrum of proflavine and its ions

, 2010
Motivated by possible astrophysical and biological applications we calculate visible and near UV spectral lines of proflavine (C13H11N3, 3,6-diaminoacridine) in vacuum, as well as its anion, cation, and dication.
A. Bonaca, Bauschlicher, Becke, Castro, Castro, Clemett, De Silvestri, Destree, Ehrenfreund, G. Bilalbegović, Giannozzi, Godby, Herbig, Hirata, Hobbs, Hudgins, Jain, Jenniskens, Jones, Koch, Kokalj, Le Page, Lee, Lepp, Lerman, Malloci, Malloci, Marques, Martin, Mataga, Neumann, Perdew, Pileni, Rappe, Rocca, Runge, Sarre, Sarre, Sarre, Schulman, Snow, Thaddeus, Tielens, Tozzini, Troullier, Tuairisg, Varsano, Walker, Weisman, Yabana   +49 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Temperature distribution in a stellar atmosphere diagnostic basis [PDF]

A stellar chromosphere is considered a region where the temperature increases outward and where the temperature structure of the gas controls the shape of the spectral lines.
Jefferies, J. T., Morrison, N. D.
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

A 1.3 cm Line Survey toward Orion KL

, 2015
Orion KL has served as a benchmark for spectral line searches throughout the (sub)millimeter regime. The main goal is to systematically study spectral characteristics of Orion KL in the 1.3 cm band. We carried out a spectral line survey (17.9 GHz to 26.2
Gong, Y., Henkel, C., Klein, B., Mao, R. Q., Menten, K. M., Spezzano, S., Thorwirth, S., Walmsley, C. M., Wyrowski, F.   +8 more
core   +1 more source